{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:47:10Z","timestamp":1789991230102,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Subpial cortical demyelination (SCD<\/jats:styled-content>) accounts for the greatest proportion of demyelinated cortex in multiple sclerosis (MS<\/jats:styled-content>). SCD<\/jats:styled-content> is already found in biopsy cases with early MS<\/jats:styled-content> and in marmosets with experimental autoimmune encephalomyelitis (EAE<\/jats:styled-content>), but the pathogenesis of SCD<\/jats:styled-content> is not well understood. The objective of this study was to investigate whether and, if so, which meningeal inflammatory cells were associated with early SCD<\/jats:styled-content> in marmosets with EAE<\/jats:styled-content>. Immunohistochemistry was performed to analyze brain samples from eight control animals and eight marmosets immunized with myelin oligodendrocyte glycoprotein. Meningeal T<\/jats:styled-content>, B<\/jats:styled-content> and plasma cells were quantified adjacent to SCD<\/jats:styled-content>, normal\u2010appearing EAE<\/jats:styled-content> cortex (NAC<\/jats:styled-content>) and control marmoset cortex. SCD<\/jats:styled-content> areas appeared mostly hypocellular with low\u2010grade microglial activation. In marmosets with EAE<\/jats:styled-content>, meninges adjacent to SCD<\/jats:styled-content> showed significantly increased T<\/jats:styled-content> cells paralleled by elevated plasma cells, but unaltered B<\/jats:styled-content> cell numbers compared with NAC<\/jats:styled-content>. The elevation of meningeal T<\/jats:styled-content> and plasma cells was a specific finding topographically associated with SCD<\/jats:styled-content>, as the meninges overlying NAC<\/jats:styled-content> displayed similarly low T<\/jats:styled-content>, B<\/jats:styled-content> and plasma cell numbers as control cortex. These findings suggest that local meningeal T<\/jats:styled-content> and plasma cell infiltration contributes to the pathogenesis of SCD<\/jats:styled-content> in marmosets with EAE<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bpa.12180","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T11:14:35Z","timestamp":1405682075000},"page":"276-286","source":"Crossref","is-referenced-by-count":19,"title":["Increased Meningeal T<\/scp> and Plasma Cell Infiltration is Associated with Early Subpial Cortical Demyelination in Common Marmosets with Experimental Autoimmune Encephalomyelitis"],"prefix":"10.1111","volume":"25","author":[{"given":"Nadine","family":"Kramann","sequence":"first","affiliation":[{"name":"Institute of Neuropathology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Neid","sequence":"additional","affiliation":[{"name":"Institute of 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