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However, the role that age plays in the susceptibility of the brain to these <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> pathologies and the relationships between them is still not well understood. This study investigated the age\u2010related response to intracerebroventricular injection of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2<jats:sub>25\u201335<\/jats:sub> in 3\u2010, 6\u2010 and 9\u2010month\u2010old rats. <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 toxicity resulted in an age\u2010related increase in cholinergic loss and microglial activation in the basal forebrain along with neuronal loss in the hippocampal <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 subfield. Performance in the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>orris water maze revealed impairments in long\u2010term reference memory in 6\u2010month\u2010old <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 administered animals, which was not seen in 3\u2010month\u2010old animals. These results support a role of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 administration in inducing age\u2010dependent cholinergic loss and neuroinflammation, and additionally provide evidence for a more age\u2010appropriate model of adult\u2010onset <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 toxicity demonstrating pathological changes that reflect the early stages of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> pathogenesis including neuroinflammation, cholinergic loss and beginning stages of memory impairment.<\/jats:p>","DOI":"10.1111\/bpa.12199","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T10:38:12Z","timestamp":1409740692000},"page":"531-542","source":"Crossref","is-referenced-by-count":18,"title":["Age\u2010Dependent Effect of \u03b2\u2010Amyloid Toxicity on Basal Forebrain Cholinergic Neurons and Inflammation in the Rat 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