{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:53:05Z","timestamp":1787507585194,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>\n \n Pilomyxoid astrocytomas (\n PMAs<\/jats:styled-content>\n ) manifest a more aggressive clinical course than pilocytic astrocytomas (\n PAs<\/jats:styled-content>\n ). Development of effective therapies demands a better biological understanding of\n PMA<\/jats:styled-content>\n . We first conducted gene expression microarray analysis of 9\n PMA<\/jats:styled-content>\n and 13\n PA<\/jats:styled-content>\n from infra\u2010 and supratentorial sites. Unsupervised hierarchical clustering analysis demonstrated that tumors are grouped according to anatomic site, not diagnosis. Gene expression profiles were then contrasted between eight\n PMAs<\/jats:styled-content>\n and six\n PAs<\/jats:styled-content>\n , all supratentorial\/hypothalamic\/chiasmal. Clinical outcome of\n PMAs<\/jats:styled-content>\n varied, with four out of four patients with diencephalic syndrome succumbing to disease, one of whom showed bulky metastatic leptomeningeal spread at autopsy, with bimodal maturation to\n PA<\/jats:styled-content>\n in some areas and de\u2010differentiation to glioblastoma in others. A surviving child has undergone multiple surgical debulking, with progressive maturation to\n PA<\/jats:styled-content>\n over time. Ontology\u2010enrichment analysis identified overexpression in\n PMAs<\/jats:styled-content>\n of extracellular matrix and mitosis\u2010related genes. Genes overexpressed in\n PMA<\/jats:styled-content>\n vs.\n PA<\/jats:styled-content>\n , ranked according to fold\u2010change, included developmental genes\n \n H19<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n DACT2<\/jats:italic>\n <\/jats:styled-content>\n , extracellular matrix collagens (\n COL2A1<\/jats:styled-content>\n ;\n COL1A1<\/jats:styled-content>\n ) and\n \n IGF2BP3<\/jats:italic>\n <\/jats:styled-content>\n (\n IMP3<\/jats:styled-content>\n ), the latter previously identified as an adverse prognostic factor in\n PMA<\/jats:styled-content>\n and\n PA<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/bpa.12239","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T01:47:24Z","timestamp":1418953644000},"page":"429-440","source":"Crossref","is-referenced-by-count":28,"title":["Pilomyxoid Astrocytoma (\n PMA<\/scp>\n ) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (\n PA<\/scp>\n ) and Variable Tendency Toward Maturation to\n PA<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"given":"Bette K.","family":"Kleinschmidt\u2010DeMasters","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Colorado School of Medicine Aurora CO"},{"name":"Department of Neurosurgery The University of Colorado School of Medicine Aurora CO"},{"name":"Department of Neurology The University of Colorado School of Medicine Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Donson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Colorado School of Medicine Aurora CO"},{"name":"Children's Hospital Colorado Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Palo Alto CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas K.","family":"Foreman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The University of Colorado School of Medicine Aurora CO"},{"name":"Department of Neurology The University of Colorado School of Medicine Aurora CO"},{"name":"Department of Pediatrics The University of Colorado School of Medicine Aurora CO"},{"name":"Children's Hospital Colorado Aurora 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