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Most instances of\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    occur in association with the play of sports, but\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    has also been reported in association with blast injuries and other neurotrauma. Symptoms of\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    include behavioral and mood changes, memory loss, cognitive impairment and dementia. Like many other neurodegenerative diseases,\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    is diagnosed with certainty only by neuropathological examination of brain tissue.\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    is a tauopathy characterized by the deposition of hyperphosphorylated tau (p\u2010tau) protein as neurofibrillary tangles, astrocytic tangles and neurites in striking clusters around small blood vessels of the cortex, typically at the sulcal depths. Severely affected cases show p\u2010tau pathology throughout the brain. Abnormalities in phosphorylated 43\u2009k\n                    <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                    a\n                    <jats:styled-content style=\"fixed-case\">TAR DNA<\/jats:styled-content>\n                    \u2010binding protein are found in most cases of\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    ; beta\u2010amyloid is identified in 43%, associated with age. Given the importance of sports participation and physical exercise to physical and psychological health as well as disease resilience, it is critical to identify the genetic risk factors for\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    as well as to understand how other variables, such as stress, age at exposure, gender, substance abuse and other exposures, contribute to the development of\n                    <jats:styled-content style=\"fixed-case\">CTE<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/bpa.12248","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T03:43:06Z","timestamp":1429760586000},"page":"350-364","source":"Crossref","is-referenced-by-count":526,"title":["The Neuropathology of Chronic Traumatic Encephalopathy"],"prefix":"10.1111","volume":"25","author":[{"given":"Ann C.","family":"McKee","sequence":"first","affiliation":[{"name":"VA Boston Healthcare System Boston University  Boston MA"},{"name":"Department of Pathology and Laboratory Science Boston University School of Medicine Boston University  Boston MA"},{"name":"Department of Neurology Boston University School of Medicine Boston University  Boston MA"},{"name":"Boston University Alzheimer's Disease Center Boston University  Boston MA"},{"name":"Chronic Traumatic Encephalopathy Center Program Boston University  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor D.","family":"Stein","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System Boston University  Boston MA"},{"name":"Department of Pathology and Laboratory Science Boston University School of Medicine Boston University  Boston MA"},{"name":"Boston University Alzheimer's Disease Center Boston University  Boston MA"},{"name":"Chronic Traumatic Encephalopathy Center Program Boston University  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University School of Medicine Boston University  Boston MA"},{"name":"Chronic Traumatic Encephalopathy Center Program Boston University  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University School of Medicine Boston University  Boston MA"},{"name":"Chronic Traumatic Encephalopathy Center Program Boston University  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511065103"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq263"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-014-0306-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094734"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12184"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91712-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00955101"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl269"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070182"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1308"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122059"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-35491-5_7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12197"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-010-0243-5"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-008-9510-3"},{"key":"e_1_2_5_19_1","first-page":"117","article-title":"[Generalized Alzheimer's neurofibrillary lesions without senile plaques. 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