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It has been suggested that exercise might ameliorate the disease; here, we evaluated the effect of voluntary running on several aspects of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> including amyloid deposition, tau phosphorylation, inflammatory reaction, neurogenesis and spatial memory in the double transgenic <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>swe\/<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>1\u0394<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>9 mouse model of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. We report that voluntary wheel running for 10 weeks decreased <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 burden, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hioflavin\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\u2010positive plaques and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u03b2 oligomers in the hippocampus. In addition, runner <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>swe\/<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>1\u0394<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>9 mice showed fewer phosphorylated tau protein and decreased astrogliosis evidenced by lower staining of <jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>. Further, runner <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>swe\/<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>1\u0394<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>9 mice showed increased number of neurons in the hippocampus and exhibited increased cell proliferation and generation of cells positive for the immature neuronal protein doublecortin, indicating that running increased neurogenesis. Finally, runner <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>swe\/<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>1\u0394<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>9 mice showed improved spatial memory performance in the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>orris water maze. Altogether, our findings indicate that in <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>swe\/<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>1\u0394<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>9 mice, voluntary running reduced all the neuropathological hallmarks of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> studied, reduced neuronal loss, increased hippocampal neurogenesis and reduced spatial memory loss. These findings support that voluntary exercise might have therapeutic value on <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bpa.12255","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T10:08:51Z","timestamp":1426068531000},"page":"62-74","source":"Crossref","is-referenced-by-count":158,"title":["Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of <scp>A<\/scp>lzheimer's Disease"],"prefix":"10.1111","volume":"26","author":[{"given":"Cheril","family":"Tapia\u2010Rojas","sequence":"first","affiliation":[{"name":"Centro de Envejecimiento y Regeneraci\u00f3n (CARE) Departamento de Biolog\u00eda Celular y Molecular Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile  Santiago 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