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Our aim was to evaluate the functional integrity of the auditory pathway and to visualize, by histological and cellular methods, the damage to the brainstem using a neonatal rat model of<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>brain injury. To carry out this morphofunctional evaluation, we studied the effects of the administration of the antioxidants nicotine, melatonin, resveratrol and docosahexaenoic acid after hypoxia\u2010ischemia on the inferior colliculus and the auditory pathway. We found that the integrity of the auditory pathway in the brainstem was altered as a consequence of the<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>insult. Thus, the auditory brainstem response (<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>) showed increased<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>wave latencies. At a histological level, HI altered the morphology of the inferior colliculus neurons, astrocytes and oligodendricytes, and at a molecular level, the mitochondria membrane potential and integrity was altered during the first hours after the<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>and reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>) activity is increased 12\u2009h after the injury in the brainstem. Following antioxidant treatment,<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>interpeak latency intervals were restored and the body and brain weight was recovered as well as the morphology of the inferior colliculus that was similar to the control group. Our results support the hypothesis that antioxidant treatments have a protective effect on the functional changes of the auditory pathway and on the morphological damage which occurs after<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>insult.<\/jats:p>","DOI":"10.1111\/bpa.12272","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T07:05:00Z","timestamp":1432105500000},"page":"186-198","source":"Crossref","is-referenced-by-count":28,"title":["Antioxidant Treatments Recover the Alteration of Auditory\u2010Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat"],"prefix":"10.1111","volume":"26","author":[{"given":"Miren","family":"Revuelta","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Histology School of Medicine and Dentistry University of the Basque Country Leioa 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