{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:26:27Z","timestamp":1789395987175,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Innovative Medizinische Forschung M\u00fcnster","award":["IMF HA 221211"],"award-info":[{"award-number":["IMF HA 221211"]}]},{"name":"German Cancer Research Center-Heidelberg Center for Personalized Oncology (DKFZ-HIPO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Papillary tumor of the pineal region (<jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content>) is a neuroepithelial brain tumor, which might pose diagnostic difficulties and recurs often. Little is known about underlying molecular alterations. We therefore investigated chromosomal copy number alterations, <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation patterns and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression profiles in a series of 24 <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content>s. Losses of chromosome 10 were identified in all 13 <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content>s examined. Losses of chromosomes 3 and 22q (54%) as well as gains of chromosomes 8p (62%) and 12 (46%) were also common. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation profiling using <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>llumina 450k arrays reliably distinguished <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content> from ependymomas and pineal parenchymal tumors of intermediate differentiation. <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content> could be divided into two subgroups based on methylation pattern, <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content> group 2 showing higher global methylation and a tendency toward shorter progression\u2010free survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.06). Genes overexpressed in <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content> as compared with ependymal tumors included <jats:styled-content style=\"fixed-case\"><jats:italic>SPDEF<\/jats:italic><\/jats:styled-content>, known to be expressed in the rodent subcommissural organ. Notable <jats:styled-content style=\"fixed-case\">SPDEF<\/jats:styled-content> protein expression was encountered in 15\/19 <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content>s as compared with only 2\/36 ependymal tumors, 2\/19 choroid plexus tumors and 0\/23 samples of other central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) tumor entities. In conclusion, <jats:styled-content style=\"fixed-case\">PTPR<\/jats:styled-content>s show typical chromosomal alterations as well as distinct <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation and expression profiles, which might serve as useful diagnostic tools.<\/jats:p>","DOI":"10.1111\/bpa.12282","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T08:07:46Z","timestamp":1435219666000},"page":"199-205","source":"Crossref","is-referenced-by-count":56,"title":["Papillary Tumor of the Pineal Region: A Distinct Molecular Entity"],"prefix":"10.1111","volume":"26","author":[{"given":"Stephanie","family":"Heim","sequence":"first","affiliation":[{"name":"Institute of Neuropathology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sill","sequence":"additional","affiliation":[{"name":"Division of Biostatistics German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurooncology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Vasiljevic","sequence":"additional","affiliation":[{"name":"Centre de Pathologie et Neuropathologie Est Centre de Biologie et Pathologie Est Groupement Hospitalier Est Hospices Civils de Lyon  Bron Cedex France"},{"name":"CRNL INSERM U1028 CNRS UMR 5292 Equipe Neuro\u2010oncologie et Neuro\u2010inflammation Universit\u00e9 de Lyon  Lyon Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Jouvet","sequence":"additional","affiliation":[{"name":"Centre de Pathologie et Neuropathologie Est Centre de Biologie et Pathologie Est Groupement Hospitalier Est Hospices Civils de Lyon  Bron Cedex 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