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Gliosarcomas and giant cell glioblastomas are rare histological glioblastoma variants, which usually develop rapidly. We determined the genetic patterns of 36 gliosarcomas and 19 giant cell glioblastomas. <jats:italic>IDH1<\/jats:italic> and <jats:italic>IDH2<\/jats:italic> mutations were absent in all 36 gliosarcomas and in 18 of 19 giant cell glioblastomas analyzed, indicating that they are histological variants of primary glioblastoma. Furthermore, LOH 10q (88%) and <jats:italic>TERT<\/jats:italic> promoter mutations (83%) were frequent in gliosarcomas. Copy number profiling using the 450k methylome array in 5 gliosarcomas revealed <jats:italic>CDKN2A<\/jats:italic> homozygous deletion (3 cases), trisomy chromosome 7 (2 cases), and monosomy chromosome 10 (2 cases). Giant cell glioblastomas had LOH 10q in 50% and LOH 19q in 42% of cases. ATRX loss was detected immunohistochemically in 19% of giant cell glioblastomas, but absent in 17 gliosarcomas. These and previous results suggest that gliosarcomas are a variant of, and genetically similar to, primary glioblastomas, except for a lack of <jats:italic>EGFR<\/jats:italic> amplification, while giant cell glioblastoma occupies a hybrid position between primary and secondary glioblastomas.<\/jats:p>","DOI":"10.1111\/bpa.12328","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T08:40:38Z","timestamp":1444207238000},"page":"517-522","source":"Crossref","is-referenced-by-count":64,"title":["Genetic Alterations in Gliosarcoma and Giant Cell Glioblastoma"],"prefix":"10.1111","volume":"26","author":[{"given":"Ji Eun","family":"Oh","sequence":"first","affiliation":[{"name":"Section of Molecular Pathology, International Agency for Research on Cancer F\u201069372 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Section of Molecular Pathology, International 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