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Clinical heterogeneity is a well\u2010recognized feature of the disease as age of onset, site of onset and the duration of the disease can vary greatly among patients. A number of genes have been identified and associated to familial and sporadic forms of ALS but the majority of cases remains still unexplained. Recent breakthrough discoveries have demonstrated that clinical manifestations associated with ALS\u2010related genes are not circumscribed to motor neurons involvement. In this view, ALS appears to be linked to different conditions over a continuum or spectrum in which overlapping phenotypes may be identified. In this review, we aim to examine the increasing number of <jats:italic>spectra<\/jats:italic>, including ALS\/Frontotemporal Dementia and ALS\/Myopathies <jats:italic>spectra<\/jats:italic>. 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