{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:07:05Z","timestamp":1790186825762,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571284 and 81200879"],"award-info":[{"award-number":["81571284 and 81200879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the neuroprotective effects of hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) have been demonstrated in several studies, whether H<jats:sub>2<\/jats:sub>S protects against early brain injury (EBI) and secondary cognitive dysfunction in subarachnoid hemorrhage (SAH) model remains unknown. This study was undertaken to evaluate the influence of H<jats:sub>2<\/jats:sub>S on both acute brain injury and neurobehavioral changes as well as the underlying mechanisms after SAH. The H<jats:sub>2<\/jats:sub>S donor, NaHS, was administered via an intraperitoneal injection at a dose of 5.6 mg\/kg at 2 h, 6 h, 24 h, and 46 h after SAH in rat model. The results showed that NaHS treatment significantly improved brain edema and neurobehavioral function, and attenuated neuronal cell death in the prefrontal cortex, associated with a decrease in Bax\/Bcl\u20102 ratio and suppression of caspase\u20103 activation at 48 h after SAH. NaHS also promoted phospho\u2010Akt and phospho\u2010ERK levels. Furthermore, NaHS treatment significantly enhanced the levels of brain\u2010derived neurotrophic factor (BDNF) and phospho\u2010CREB. Importantly, NaHS administration improved learning and memory performance in the Morris water maze test at 7 days post\u2010SAH in rats. These results demonstrated that NaHS, as an exogenous H<jats:sub>2<\/jats:sub>S donor, could significantly alleviate the development of EBI and cognitive dysfunction induced by SAH via Akt\/ERK\u2010related antiapoptosis pathway, and upregulating BDNF\u2010CREB expression.<\/jats:p>","DOI":"10.1111\/bpa.12361","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T08:05:01Z","timestamp":1454054701000},"page":"51-63","source":"Crossref","is-referenced-by-count":41,"title":["Neuroprotective Effects of Hydrogen Sulfide Against Early Brain Injury and Secondary Cognitive Deficits Following Subarachnoid Hemorrhage"],"prefix":"10.1111","volume":"27","author":[{"given":"Tong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University 107#, Wenhua Xi Road Jinan, Shandong Province 250012 P.R. 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