{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:39:24Z","timestamp":1783028364804,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adipsic (or essential) hypernatremia is a rare hypernatremia caused by a deficiency in thirst regulation and vasopressin release. In 2010, we reported a case in which autoantibodies targeting the sensory circumventricular organs (sCVOs) caused adipsic hypernatremia without hypothalamic structural lesions demonstrable by magnetic resonance imaging (MRI); sCVOs include the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), which are centers for the monitoring of body\u2010fluid conditions and the control of water and salt intakes, and harbor neurons innervating hypothalamic nuclei for vasopressin release. We herein report three newly identified patients (3\u2010 to 8\u2010year\u2010old girls on the first visit) with similar symptoms. The common features of the patients were extensive hypernatremia without any sensation of thirst and defects in vasopressin response to serum hypertonicity. Despite these features, we could not detect any hypothalamic structural lesions by MRI. Immunohistochemical analyses using the sera of the three patients revealed that antibodies specifically reactive to the mouse SFO were present in the sera of all cases; in one case, the antibodies also reacted with the mouse OVLT. The immunoglobulin (Ig) fraction of serum obtained from one patient was intravenously injected into wild\u2010type mice to determine whether the mice developed similar symptoms. Mice injected with a patient's Ig showed abnormalities in water\/salt intake, vasopressin release, and diuresis, which resultantly developed hypernatremia. Prominent cell death and infiltration of reactive microglia was observed in the SFO of these mice. Thus, autoimmune destruction of the SFO may be the cause of the adipsic hypernatremia. This study provides a possible explanation for the pathogenesis of adipsic hypernatremia without demonstrable hypothalamus\u2010pituitary lesions.<\/jats:p>","DOI":"10.1111\/bpa.12409","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T08:28:54Z","timestamp":1466756934000},"page":"323-331","source":"Crossref","is-referenced-by-count":36,"title":["Adipsic hypernatremia without hypothalamic lesions accompanied by autoantibodies to subfornical organ"],"prefix":"10.1111","volume":"27","author":[{"given":"Takeshi Y.","family":"Hiyama","sequence":"first","affiliation":[{"name":"Division of Molecular Neurobiology National Institute for Basic Biology (NIBB) Okazaki Aichi 444\u20108787 Japan"},{"name":"School of Life Science SOKENDAI (The Graduate University for Advanced Studies) Okazaki Aichi 444\u20108787 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari 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