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Neuronal dysfunction and neuronal death in HD are caused by a combination of interrelated pathogenic processes that lead to motor, cognitive and psychiatric symptoms. Understanding how mutant huntingtin impacts on a plethora of cellular functions could help to identify new molecular targets. Although HD has been classically classified as a neurodegenerative disease affecting voluntary movement, lately cognitive dysfunction is receiving increased attention as it is very invalidating for patients. Thus, an ambitious goal in HD research is to find altered molecular mechanisms that contribute to cognitive decline. In this review, we have focused on those findings related to corticostriatal and hippocampal cognitive dysfunction in HD, as well as on the underlying molecular mechanisms, which constitute potential therapeutic targets. These include alterations in synaptic plasticity, transcriptional machinery and neurotrophic and neurotransmitter signaling.<\/jats:p>","DOI":"10.1111\/bpa.12432","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T16:38:37Z","timestamp":1471365517000},"page":"752-771","source":"Crossref","is-referenced-by-count":37,"title":["Cognitive dysfunction in <scp>H<\/scp>untington's disease: mechanisms and therapeutic strategies beyond <scp>BDNF<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"given":"Mar","family":"Puigdell\u00edvol","sequence":"first","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina Universitat de Barcelona Barcelona Catalonia Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) sobre Enfermedades Neurodegenerativas (CIBERNED)  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