{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:18Z","timestamp":1789628538720,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IgG4\u2010related disease is an immune\u2010mediated disease with manifestations in most organ systems among them the pituitary gland. To date, few cases of histologically confirmed cases of IgG\u2010related hypophysitis have been reported. The aim of this study was to retrospectively determine the prevalence of IgG4\u2010related hypophysitis among cases previously diagnosed as primary hypophysitis (lymphocytic hypophysitis, granulomatous hypophysitis and hypophysitis not otherwise specified). Histological and immunohistochemical analysis revealed that 12 of 29 cases (41.4%) previously diagnosed as primary hypophysitis fulfilled the criteria for IgG4\u2010related disease and, thus, IgG4\u2010related hypophysitis should always be considered in the differential diagnosis of primary hypophysitis. All cases of IgG4\u2010related hypophysitis showed a dense lymphoplasmacytic infiltrate with more than 10 IgG4\u2010positive cells per high power field and a ratio of IgG4\/IgG\u2010positive cells of more than 40%, whereas storiform fibrosis was an inconsistent histological feature and was also seen in few cases of non\u2010IgG\u2010related hypophysitis, thus lacking sensitivity and specificity. Obliterative phlebitis was not seen in any case. Thus, histological criteria defined for IgG4\u2010related disease in other organs should be modified for IgG4\u2010related hypophysitis, accordingly.<\/jats:p>","DOI":"10.1111\/bpa.12459","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T06:42:40Z","timestamp":1479537760000},"page":"839-845","source":"Crossref","is-referenced-by-count":52,"title":["IgG4\u2010related hypophysitis is highly prevalent among cases of histologically confirmed hypophysitis"],"prefix":"10.1111","volume":"27","author":[{"given":"Christian","family":"Bernreuther","sequence":"first","affiliation":[{"name":"Institute of Neuropathology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Illies","sequence":"additional","affiliation":[{"name":"Department of Pathology Karolinska Institute and University Hospital Stockholm 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