{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:18:58Z","timestamp":1790083138482,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clear cell meningioma (CCM) is a rare grade II histopathological subtype that usually occurs in young patients and displays high recurrence rate. Germline <jats:italic>SMARCE1<\/jats:italic> mutations have been described in hereditary forms of this disease and more recently in small syndromic and sporadic CCM series. The diagnostic value of SMARCE1 in distinguishing between CCM and other meningioma variants has not been yet established. The aim of our study was to investigate the status of SMARCE1 in a series of CCMs and its morphological mimickers. We compared the performance of an anti\u2010SMARCE1 antibody and the molecular analysis of the <jats:italic>SMARCE1<\/jats:italic> gene in a retrospective multicenter series of CCMs. All CCMs lossed SMARCE1 immunoexpression. Bi\u2010allelic inactivating events were found by NGS\u2010based sequencing in all of these cases, except for one, which was incompletely explored, but had a wild\u2010type sequence. We then validated the anti\u2010SMARCE1 antibody specificity by analyzing additional 305 pediatric and adult meningiomas of various subtypes and 15 non\u2010meningioma clear cell tumors by SMARCE1 immunohistochemistry. A nuclear immunostaining was preserved in all other meningioma variants, as well as non\u2010meningioma clear cell tumors. In conclusion, our series showed, for the first time, that SMARCE1 immunostaining is a highly sensitive biomarker for CCM, useful as a routine diagnostic biomarker.<\/jats:p>","DOI":"10.1111\/bpa.12524","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T11:38:43Z","timestamp":1493984323000},"page":"466-474","source":"Crossref","is-referenced-by-count":70,"title":["Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-5828","authenticated-orcid":false,"given":"Arnault","family":"Tauziede\u2010Espariat","sequence":"first","affiliation":[{"name":"Department of Neuropathology Sainte\u2010Anne Hospital 75014 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Parfait","sequence":"additional","affiliation":[{"name":"Department of 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