{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:07:35Z","timestamp":1792814855543,"version":"4.5.0"},"reference-count":141,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T00:00:00Z","timestamp":1501977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430021, 81370470"],"award-info":[{"award-number":["81430021, 81370470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HC: AG000928, 000959"],"award-info":[{"award-number":["HC: AG000928, 000959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The most prevalent pathological features of many neurodegenerative diseases are the aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy, as major intracellular machinery for degrading aggregated proteins and damaged organelles, has been reported to be involved in the occurrence of pathological changes in many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. In this review, we summarize most recent research progress in this topic and provide a new perspective regarding autophagy regulation on the pathogenesis of neurodegenerative diseases. Finally, we discuss the signaling molecules in autophagy\u2010related pathways as therapeutic targets for the treatment of these diseases.<\/jats:p>","DOI":"10.1111\/bpa.12545","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T11:29:48Z","timestamp":1499945388000},"page":"3-13","source":"Crossref","is-referenced-by-count":420,"title":["Autophagy in neurodegenerative diseases: pathogenesis and therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"Fang","family":"Guo","sequence":"first","affiliation":[{"name":"The Key Laboratory of Stem Cell Biology and Neurogenomic Laboratory Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences &amp; Shanghai Jiao Tong University School of Medicine Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Research Center on Neurological Diseases the First Affiliated Hospital, Dalian Medical University Dalian 116011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin","family":"Cai","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-2705","authenticated-orcid":false,"given":"Weidong","family":"Le","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Stem Cell Biology and Neurogenomic Laboratory Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences &amp; Shanghai Jiao Tong University School of Medicine Shanghai 200025 China"},{"name":"Clinical Research Center on Neurological Diseases the First Affiliated Hospital, Dalian Medical University Dalian 116011 China"},{"name":"Collaborative Innovation Center for Brain Science the First Affiliated Hospital, Dalian Medical University Dalian 116011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20414"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.648998"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3050"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11803"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0800-08.2008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07098.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705235114"},{"key":"e_1_2_11_9_1","first-page":"201705235","article-title":"Bidirectional regulation of A\u03b2 levels by Presenilin 1","author":"Bustos V","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.100420"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00277.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204861200"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.25188"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.318"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.08.012"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.79"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1205406"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065367"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402099"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305623110"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1920-10.2010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10353"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22728"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12108"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1648-8"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016472108"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.040"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200702115"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708022105"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.013"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.9.2364.2364"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0165-0"},{"key":"e_1_2_11_35_1","first-page":"1","article-title":"A central role for phosphorylated p38a in linking proteasome inhibition\u2010induced apoptosis and autophagy","volume":"3","author":"Guo F","year":"2016","journal-title":"Mol Neurobiol"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200505082"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2010.01.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt192"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3689"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20071619"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.001"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.02.008"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"a024240","DOI":"10.1101\/cshperspect.a024240","article-title":"Huntington's disease: mechanisms of pathogenesis and therapeutic strategies","volume":"7","author":"Jimenez\u2010Sanchez M","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4496"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.21.5720"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23746"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201402104"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4001"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13127"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120819"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2755"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.10.066"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.11.003"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19496"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04723"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.12.047"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13392"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608432113"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3809-03.2004"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.050"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.008"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.12.17956"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6412-10.2011"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.01.014"},{"key":"e_1_2_11_65_1","first-page":"37","article-title":"Defining and measuring autophagosome flux\u2010concept and reality","volume":"8627","author":"Loos B","year":"2014","journal-title":"Autophagy"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1112-3"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.46.27531"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025416"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2528"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-011-0149-7"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200910140"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.07.039"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.06.017"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3961"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2010.10.010"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0873-9"},{"key":"e_1_2_11_77_1","first-page":"302","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Mizushima N","year":"2006","journal-title":"Nature"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06639"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154005"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523810113"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5998"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.06.045"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201008167"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26141"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000298"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200809125"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.2.113"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008839"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6790"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01453-06"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2003.12.004"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1208889"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.07.085"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1971"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.07.002"},{"key":"e_1_2_11_97_1","first-page":"2190","article-title":"The autophagy\u2010related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid\u2010\u03b2 accumulation in mice","volume":"118","author":"Pickford F","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0292-9"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05217.x"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.044"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1884"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1591"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1362"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.05.014"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.11.003"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq093"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.034"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0022-y"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20130134"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609532200"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504035"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.110"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182160690"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204592"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.3270"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600364200"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.2.031"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.106"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2007.01050.x"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm985"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5575-11.2012"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-12-1249"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-03-0312"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70213-7"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.060061"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206362109"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300227200"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.07.004"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12169"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1009792"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26373"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl501839q"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.08.015"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu278"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200904075"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.03.018"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.446385"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4828"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.27710"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.4.14541"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000838"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4790-12.2013"}],"container-title":["Brain Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbpa.12545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T09:55:02Z","timestamp":1695462902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bpa.12545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,6]]},"references-count":141,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/bpa.12545"],"URL":"https:\/\/doi.org\/10.1111\/bpa.12545","archive":["Portico"],"relation":{},"ISSN":["1015-6305","1750-3639"],"issn-type":[{"value":"1015-6305","type":"print"},{"value":"1750-3639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,6]]}}}