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Recently, the presence of fetal\u2010in\u2010maternal microchimeric cells has been shown to have prognostic significance in breast and colorectal cancers. The frequency and potential role of these cells has not been investigated in brain tumors. We therefore selected two common primary adult brain tumors for this purpose: meningioma, which is sex hormone responsive and has a higher incidence in women, and glioblastoma, which is sex hormone independent and occurs more commonly in men. Quantitative PCR was used to detect the presence of male DNA in tumor samples from women with a positive history of male pregnancy and a diagnosis of either glioblastoma or meningioma. Fluorescence <jats:italic>in situ<\/jats:italic> hybridization for the X and Y chromosomes was used to verify the existence of intact male cells within tumor tissue. Fetal microchimerism was found in approximately 80% of glioblastoma cases and 50% of meningioma cases. No correlations were identified between the presence of microchimerism and commonly used clinical or molecular diagnostic features of disease. The impact of fetal microchimeric cells should be evaluated prospectively.<\/jats:p>","DOI":"10.1111\/bpa.12557","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T15:02:16Z","timestamp":1505746936000},"page":"484-494","source":"Crossref","is-referenced-by-count":31,"title":["Fetal microchimerism in human brain tumors"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-3986","authenticated-orcid":false,"given":"Lauren","family":"Broestl","sequence":"first","affiliation":[{"name":"Department of Pediatrics Washington University School of Medicine St. Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University School of Medicine St. Louis MO"},{"name":"Department of Neuroscience Washington University School of Medicine St. Louis 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