{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:08:37Z","timestamp":1789952917916,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2011\u201023034"],"award-info":[{"award-number":["BFU2011\u201023034"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adenosine, hypoxanthine, xanthine, guanosine and inosine levels were assessed by HPLC, and the activity of related enzymes 5\u2032\u2010nucleotidase (5\u2032\u2010NT), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal (PC) and temporal (TC) cortices at different stages of disease progression in Alzheimer's disease (AD) and in age\u2010matched controls. Significantly decreased levels of adenosine, guanosine, hypoxanthine and xanthine, and apparently less inosine, are found in FC from the early stages of AD; PC and TC show an opposing pattern, as adenosine, guanosine and inosine are significantly increased at least at determinate stages of AD whereas hypoxanthine and xanthine levels remain unaltered. 5\u2032\u2010NT is reduced in membranes and cytosol in FC mainly at early stages but not in PC, and only at advanced stages in cytosol in TC. ADA activity is decreased in AD when considered as a whole but increased at early stages in TC. Finally, PNP activity is increased only in TC at early stages. Purine metabolism alterations occur at early stages of AD independently of neurofibrillary tangles and \u03b2\u2010amyloid plaques. Alterations are stage dependent and region dependent, the latter showing opposite patterns in FC compared with PC and TC. Adenosine is the most affected of the assessed purines.<\/jats:p>","DOI":"10.1111\/bpa.12592","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T07:26:57Z","timestamp":1516778817000},"page":"933-946","source":"Crossref","is-referenced-by-count":84,"title":["Purine\u2010related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology"],"prefix":"10.1111","volume":"28","author":[{"given":"Patricia","family":"Alonso\u2010Andr\u00e9s","sequence":"first","affiliation":[{"name":"Facultad de Ciencias y Tecnolog\u00edas Qu\u00edmicas\/Facultad de Medicina de Ciudad Real, Departamento de Qu\u00edmica Inorg\u00e1nica Org\u00e1nica y Bioqu\u00edmica, Centro Regional de Investigaciones Biom\u00e9dicas, Universidad de Castilla\u2010La Mancha  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 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