{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:44:16Z","timestamp":1791459856854,"version":"4.3.4"},"reference-count":211,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    ) and type 2 diabetes mellitus (T2\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    ) are highly prevalent aging\u2010related diseases associated with significant morbidity and mortality. Some findings in human and animal models have linked T2\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    to\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    \u2010type dementia. Despite epidemiological associations between the T2\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    and cognitive impairment, the interrelational mechanisms are unclear. The preponderance of evidence in longitudinal studies with autopsy confirmation have indicated that vascular mechanisms, rather than classic\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    \u2010type pathologies, underlie the cognitive decline often seen in self\u2010reported T2\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    . T2\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    is associated with cardiovascular and cerebrovascular disease (\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    ), and is associated with increased risk of infarcts and small vessel disease in the brain and other organs. Neuropathological examinations of post\u2010mortem brains demonstrated evidence of cerebrovascular disease and little to no correlation between T2\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    and \u03b2\u2010amyloid deposits or neurofibrillary tangles. Nevertheless, the mechanisms upstream of early\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    \u2010specific pathology remain obscure. In this regard, there may indeed be overlap between the pathologic mechanisms of T2\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    \/\u201cmetabolic syndrome,\u201d and\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    . More specifically, cerebral insulin processing, glucose metabolism, mitochondrial function, and\/or lipid metabolism could be altered in patients in early\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    and directly influence symptomatology and\/or neuropathology.\n                  <\/jats:p>","DOI":"10.1111\/bpa.12655","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T06:20:28Z","timestamp":1534227628000},"page":"3-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline"],"prefix":"10.1111","volume":"29","author":[{"given":"Yevgen","family":"Chornenkyy","sequence":"first","affiliation":[{"name":"University of Kentucky College of Medicine Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang\u2010Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine Lexington KY"},{"name":"Sanders\u2010Brown Center on Aging, Department of Pathology University of Kentucky Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biology University of Kentucky Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-1265","authenticated-orcid":false,"given":"Peter T.","family":"Nelson","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine Lexington KY"},{"name":"Sanders\u2010Brown Center on Aging, Department of Pathology University of Kentucky Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.12.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f4d7f8"},{"key":"e_1_2_7_4_1","first-page":"97","article-title":"Normal pressure hydrocephalus. Neuropathological study","volume":"37","author":"Akai K","year":"1987","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.980080612"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.011"},{"key":"e_1_2_7_7_1","first-page":"370","article-title":"Clinico\u2010anatomopathologic analysis of 25 patients with lacunar infarction","volume":"196","author":"Arboix A","year":"1996","journal-title":"Rev Clin Esp"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12365"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595082"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000247053.45483.4e"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9204"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.4.471"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1934"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2494"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01486-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000120374.59826.1b"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1239003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1182"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913828107"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2620"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b158"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0561fje"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.01.009"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.12.2960"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02758.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12368"},{"key":"e_1_2_7_30_1","first-page":"809","article-title":"Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study","volume":"49","author":"Cheng H","year":"2003","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010grand)"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181b970ae"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63822-9"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161256"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0023-4"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.5.971"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305799101"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03329.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3666"},{"key":"e_1_2_7_40_1","unstructured":"Dementia Fact sheet N\u00b0362 2015 World Health Organization"},{"issue":"1","key":"e_1_2_7_41_1","first-page":"51","article-title":"Mitochondria morphology and DNA content upon sublethal exposure to beta\u2010amyloid(1\u201042) peptide","volume":"32","author":"Diana A","year":"2008","journal-title":"Coll Antropol"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-48"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1868"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01359-5"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.2174\/187153012800493477"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04371.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081620098"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.12.2410"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.05.004"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.366"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700611037"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.4.753"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196507000-00008"},{"key":"e_1_2_7_54_1","first-page":"1","article-title":"Altered cerebral energy metabolism in Alzheimer's disease: a PET study","volume":"35","author":"Fukuyama H","year":"1994","journal-title":"J Nucl Med"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00713.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-08-02561.2001"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00536-3"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320022009"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.006"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02694.x"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm228"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000166052.89772.b5"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05726.x"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8092-x"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00332.x"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00997.x"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.05.010"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5.1306"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1208"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R046094"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0978fje"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100018539"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.043"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2004.02.003"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15621574"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90035-3"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2.474"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197007000-00009"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.12.030"},{"key":"e_1_2_7_80_1","first-page":"415","article-title":"Abnormalities of the glucose transporter at the blood\u2010brain barrier and in brain in Alzheimer's disease","volume":"317","author":"Kalaria RN","year":"1989","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.12.1327"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03290450033020"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142262"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200008)48:2<148::AID-ANA3>3.0.CO;2-7"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.06.026"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(73)90108-1"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00503-9"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.006"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.07.031"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000184521.80820.e4"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7115.1045"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.04.013"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1450"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009106"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2016.07.003"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02887-1"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200418704"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011608"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.9.1567"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.008"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1410-3"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.057"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091230"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32052-6"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.20.11056"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr139"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1163"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030442"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642016dn11-040010"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181eee25f"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.496513"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100029930"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00181059"},{"key":"e_1_2_7_115_1","first-page":"1238","article-title":"A diagnostic approach in Alzheimer's disease using three\u2010dimensional stereotactic surface projections of fluorine\u201018\u2010FDG PET","volume":"36","author":"Minoshima S","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3877"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2009.42.8.475"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.09.006"},{"key":"e_1_2_7_119_1","first-page":"1049","article-title":"Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non\u2010alcoholic steatohepatitis","volume":"10","author":"Monte SM","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170829"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-003-0007-9"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00118"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0506"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00244.x"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31825018f7"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181919a48"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00345"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2002.29276"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-04-02047.1994"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.6.527"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.2.113"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.01.021"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1672"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32832d2e6a"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2012.68"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.1937"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2004.06.012"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1256"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90186-4"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(80)90220-7"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011603916962"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1197416"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.013"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000172"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1001-905"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/73873"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1945"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2004.07.002"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.13.1.16"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0422"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.03.016"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341202"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2635903100"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1796"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.47.1.387"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.10.1486"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.11.020"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03075-4"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.053645"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0996-2"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1227"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21142"},{"key":"e_1_2_7_167_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110224"},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb04536.x"},{"key":"e_1_2_7_169_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200102000-00037"},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6460"},{"key":"e_1_2_7_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350507"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000665"},{"key":"e_1_2_7_173_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11049"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386986-9.00011-9"},{"key":"e_1_2_7_175_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530350056020"},{"key":"e_1_2_7_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00123-1"},{"key":"e_1_2_7_177_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.579"},{"key":"e_1_2_7_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21208"},{"key":"e_1_2_7_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-6632(91)90010-M"},{"key":"e_1_2_7_180_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150072"},{"key":"e_1_2_7_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.09.011"},{"key":"e_1_2_7_182_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161194"},{"key":"e_1_2_7_183_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63051802.x"},{"key":"e_1_2_7_184_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R026682"},{"key":"e_1_2_7_185_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2032"},{"key":"e_1_2_7_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3946"},{"key":"e_1_2_7_187_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.43.233"},{"key":"e_1_2_7_188_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-0981"},{"key":"e_1_2_7_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.03.015"},{"key":"e_1_2_7_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21413"},{"key":"e_1_2_7_191_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxs012"},{"key":"e_1_2_7_192_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.3.398"},{"key":"e_1_2_7_193_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-05-01657.2000"},{"key":"e_1_2_7_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70170-9"},{"key":"e_1_2_7_195_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0470"},{"key":"e_1_2_7_196_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071208"},{"key":"e_1_2_7_197_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1357-09.2009"},{"key":"e_1_2_7_198_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804871105"},{"key":"e_1_2_7_199_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337428"},{"key":"e_1_2_7_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00965566"},{"key":"e_1_2_7_201_1","first-page":"3","article-title":"Neuropathologic changes in Alzheimer's disease: potential targets for treatment","volume":"67","author":"Wenk GL","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_202_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04794.x"},{"key":"e_1_2_7_203_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197004000-00001"},{"key":"e_1_2_7_204_1","first-page":"293","article-title":"Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women","volume":"10","author":"Yaffe K","year":"2006","journal-title":"J Nutr Health Aging"},{"key":"e_1_2_7_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/382685a0"},{"key":"e_1_2_7_206_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1996.00072.x"},{"key":"e_1_2_7_207_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1767-2"},{"key":"e_1_2_7_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001509"},{"key":"e_1_2_7_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.10.024"},{"key":"e_1_2_7_210_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2860-04.2004"},{"key":"e_1_2_7_211_1","article-title":"Metabolic alterations in cancer cells and the emerging role of oncometabolites as drivers of neoplastic change","volume":"7","author":"Zhou Z","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"e_1_2_7_212_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2014.4.203"}],"container-title":["Brain Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbpa.12655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bpa.12655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T23:12:16Z","timestamp":1694128336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bpa.12655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":211,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/bpa.12655"],"URL":"https:\/\/doi.org\/10.1111\/bpa.12655","archive":["Portico"],"relation":{},"ISSN":["1015-6305","1750-3639"],"issn-type":[{"value":"1015-6305","type":"print"},{"value":"1750-3639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"2018-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}