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BIN1 is an adaptor protein that regulates membrane dynamics in the context of endocytosis and membrane remodeling. An increase in <jats:italic>BIN1<\/jats:italic> expression and changes in the relative levels of alternatively spliced BIN1 isoforms have been reported in the brains of patients with AD. BIN1 can bind to Tau, and an increase in BIN1 expression correlates with Tau pathology. In contrast, the loss of BIN1 expression in cultured cells elevates A\u03b2 production and Tau propagation by insfluencing endocytosis and recycling. Here, we show that BIN1 accumulates adjacent to amyloid deposits <jats:italic>in vivo<\/jats:italic>. We found an increase in insoluble BIN1 and a striking accrual of BIN1 within and near amyloid deposits in the brains of multiple transgenic models of AD. The peri\u2010deposit aberrant BIN1 localization was conspicuously different from the accumulation of APP and BACE1 within dystrophic neurites. Although BIN1 is highly expressed in mature oligodendrocytes, BIN1 association with amyloid deposits occurred in the absence of the accretion of other oligodendrocyte or myelin proteins. Finally, super\u2010resolution microscopy and immunogold electron microscopy analyses highlight the presence of BIN1 in proximity to amyloid fibrils at the edges of amyloid deposits. These results reveal the aberrant accumulation of BIN1 is a feature associated with AD amyloid pathology. Our findings suggest a potential role for BIN1 in extracellular A\u03b2 deposition <jats:italic>in vivo <\/jats:italic>that is distinct from its well\u2010characterized function as an adaptor protein in endocytosis and membrane remodeling.<\/jats:p>","DOI":"10.1111\/bpa.12687","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T02:29:54Z","timestamp":1543631394000},"page":"485-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Aberrant accrual of BIN1 near Alzheimer\u2019s disease amyloid deposits in transgenic models"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-4269","authenticated-orcid":false,"given":"Pierre","family":"De Rossi","sequence":"first","affiliation":[{"name":"Department of Neurobiology The University of Chicago Chicago 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