{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:11:24Z","timestamp":1792293084321,"version":"4.4.0"},"reference-count":182,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prion diseases are progressive neurodegenerative disorders affecting humans and other mammalian species. The term prion, originally put forward to propose the concept that a protein could be infectious, refers to PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    , a misfolded isoform of the cellular prion protein (PrP\n                    <jats:sup>C<\/jats:sup>\n                    ) that represents the pathogenetic hallmark of these disorders. The discovery that other proteins characterized by misfolding and seeded aggregation can spread from cell to cell, similarly to PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    , has increased interest in prion diseases. Among neurodegenerative disorders, however, prion diseases distinguish themselves for the broader phenotypic spectrum, the fastest disease progression and the existence of infectious forms that can be transmitted through the exposure to diseased tissues via ingestion, injection or transplantation. The main clinicopathological phenotypes of human prion disease include Creutzfeldt\u2013Jakob disease, by far the most common, fatal insomnia, variably protease\u2010sensitive prionopathy, and Gerstmann\u2013Str\u00e4ussler\u2013Scheinker disease. However, clinicopathological manifestations extend even beyond those predicted by this classification. Because of their transmissibility, the phenotypic diversity of prion diseases can also be propagated into syngenic hosts as prion strains with distinct characteristics, such as incubation period, pattern of PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    distribution and regional severity of histopathological changes in the brain. Increasing evidence indicates that different PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    conformers, forming distinct ordered aggregates, encipher the phenotypic variants related to prion strains. In this review, we summarize the most recent advances concerning the histo\u2010molecular pathology of human prion disease focusing on the phenotypic spectrum of the disease including co\u2010pathologies, the characterization of prion strains by experimental transmission and their correlation with the physicochemical properties of PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    aggregates.\n                  <\/jats:p>","DOI":"10.1111\/bpa.12695","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:05:16Z","timestamp":1545869116000},"page":"278-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Recent advances in the histo\u2010molecular pathology of human prion disease"],"prefix":"10.1111","volume":"29","author":[{"given":"Simone","family":"Baiardi","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Rossi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Capellari","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-9524","authenticated-orcid":false,"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"},{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES) University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25300"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2204"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90605"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.1.5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf653"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604292103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.007930-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003643"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004953"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309871"},{"key":"e_1_2_6_12_1","first-page":"414","article-title":"Fatal familiar insomnia: clinical, neurophysiological and histopathological study of two cases","volume":"21","author":"Ayuso Blanco T","year":"2006","journal-title":"Neurologia"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150668"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0693-07.2007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001419"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.12.7859-7868.1994"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70413-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004688107"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13665"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21583"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350504"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1806.120116"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/39057"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl224"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0214-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0503-z"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.1.133"},{"key":"e_1_2_6_28_1","first-page":"A235","article-title":"A novel molecular and clinico\u2010pathologic phenotype of prion disease in an American","volume":"50","author":"Capellari S","year":"1998","journal-title":"Neurology"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0760-4"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.568"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6821"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.78.082907.145410"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00144-16"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0997-1009"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.026948-0"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/383685a0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38280"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000121389"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:20:1:25"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1791-x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194516"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12150"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12461"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12408"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02390-16"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21420"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1996.tb00796.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.2.744"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63945-5.00014-3"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.04.026"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4440-12.2013"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0913-4"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294180"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050870"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1588-3"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2009.01040.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws366"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1828-9"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060003"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/38925"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820a0ab2"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.718"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/338342a0"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2010.01192.x"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12516"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.169359"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0609-x"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01126.x"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01383-16"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15369"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22264"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002242"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-80"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704597200"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0425-8"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00973.x"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02387-09"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-74"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-32"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1447-7"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12264"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12270"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2627989100"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0713-y"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1565-x"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12411"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2003.tb00025.x"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1683-0"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00198"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12681.1"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.3.559"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905273402104"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.12.2198"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24002"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12089"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12905"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl226"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214747"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006826"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131864"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2017-204794"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad5169"},{"key":"e_1_2_6_103_1","first-page":"589","article-title":"A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation","volume":"139","author":"Miyazono M","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2003.00489.x"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00572.x"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1610003"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5924-09.2010"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1995.tb01097.x"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6588-1"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420203"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020012"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313220200"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700676"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801877200"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2012.140548"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380107"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390613"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/386232a0"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8322"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1998.tb00176.x"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.9.1757"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.18.10168"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0585-1"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq234"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1002-8"},{"key":"e_1_2_6_127_1","first-page":"20","article-title":"Molecular pathology, classification, and diagnosis of sporadic human prion disease variants","volume":"50","author":"Parchi P","year":"2012","journal-title":"Folia Neuropathol"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0615442"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0152-4"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds377"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.39201"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199810000-00010"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64692-5"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012723"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066405"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20443"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2010.00439.x"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20025"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0516-2"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1848-5"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0691-0"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0501-8"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1703-0"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1638-x"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2011.01232.x"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0978-0"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0496-7"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64030-3"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409651102"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004832"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170158"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00369445"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.477547"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0011-4"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-216"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.357"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199911)46:5<693::AID-ANA3>3.0.CO;2-Z"},{"key":"e_1_2_6_158_1","first-page":"202","article-title":"The brain immune response in human prion diseases. Microglial activation and microglial disease. I. Sporadic Creutzfeldt\u2010Jakob disease","volume":"44","author":"Szpak GM","year":"2006","journal-title":"Folia Neuropathol"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07977.x"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007062200"},{"key":"e_1_2_6_161_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.470328"},{"key":"e_1_2_6_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.27"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.532"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5295.2079"},{"key":"e_1_2_6_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8426-6"},{"key":"e_1_2_6_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi025958g"},{"key":"e_1_2_6_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0879-2"},{"key":"e_1_2_6_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.632"},{"key":"e_1_2_6_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12343"},{"key":"e_1_2_6_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00755.x"},{"key":"e_1_2_6_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05403-4"},{"key":"e_1_2_6_172_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103932"},{"key":"e_1_2_6_173_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800190105"},{"key":"e_1_2_6_174_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071714-033828"},{"key":"e_1_2_6_175_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003990"},{"key":"e_1_2_6_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24463"},{"key":"e_1_2_6_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91412-9"},{"key":"e_1_2_6_178_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100543"},{"key":"e_1_2_6_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00987.x"},{"key":"e_1_2_6_180_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050766"},{"key":"e_1_2_6_181_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.4.595"},{"key":"e_1_2_6_182_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308550200"},{"key":"e_1_2_6_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22094"}],"container-title":["Brain Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbpa.12695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:43:04Z","timestamp":1694652184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bpa.12695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":182,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/bpa.12695"],"URL":"https:\/\/doi.org\/10.1111\/bpa.12695","archive":["Portico"],"relation":{},"ISSN":["1015-6305","1750-3639"],"issn-type":[{"value":"1015-6305","type":"print"},{"value":"1750-3639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]},"assertion":[{"value":"2018-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}