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Given the role of dopamine in the development of movement disorders, but also in motivation and reward, we investigated neurodegenerative pathology in dopaminergic circuitry in Parkinson's disease (PD), PD with dementia (PDD) and dementia with Lewy bodies (DLB) patients in relation to depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:bold>Methods<\/jats:bold>\n                    <\/jats:title>\n                    <jats:p>\u03b1\u2010synuclein, hyperphosphorylated tau and amyloid\u2010beta pathology was assessed in 17 DLB, 14 PDD and 8 PD cases within striatal and midbrain subregions, with neuronal cell density assessed in substantia nigra and ventral tegmental area. Additionally, we used a structural equation modeling (SEM) approach to investigate the extent to which brain connectivity might influence the deposition of pathological proteins within dopaminergic pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:bold>Results<\/jats:bold>\n                    <\/jats:title>\n                    <jats:p>\n                      A significantly higher \u03b1\u2010synuclein burden was observed in the substantia nigra (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006), ventral tegmental area (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.011) and nucleus accumbens (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.031) in LBD patients with depression. Significant negative correlations were observed between cell density in substantia nigra with Lewy body (LB) Braak stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.013), whereas cell density in ventral tegmental area showed negative correlations with LB Braak stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026) and neurofibrillary tangle Braak stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:bold>Conclusions<\/jats:bold>\n                    <\/jats:title>\n                    <jats:p>Dopaminergic \u03b1\u2010synuclein pathology appears to drive depression. Selective targeting of dopaminergic pathways may therefore provide symptomatic relief for depressive symptoms in LBD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bpa.12697","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T12:53:13Z","timestamp":1545655993000},"page":"544-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-6601","authenticated-orcid":false,"given":"Lina","family":"Patterson","sequence":"first","affiliation":[{"name":"Alzheimer's Society Doctoral Training Centre Newcastle University, Campus for Ageing and Vitality Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven 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