{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:05:33Z","timestamp":1790791533860,"version":"4.1.0"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    cIMPACT\u2010NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications. From 2016 to 2019 (Round 1), cIMPACT published four updates. Update 1 clarified the use of the term NOS (Not Otherwise Specified) and proposed use of the additional term NEC (Not Elsewhere Classified). Update 2 issued clarifications regarding two diagnoses:\n                    <jats:italic>Diffuse Midline Glioma, H3 K27M\u2010mutant<\/jats:italic>\n                    and\n                    <jats:italic>Diffuse Astrocytoma\/Anaplastic Astrocytoma, IDH\u2010mutant<\/jats:italic>\n                    . Update 3 proposed molecular criteria that could be used in the setting of an IDH\u2010wildtype diffuse or anaplastic astrocytic glioma without histological features of glioblastoma to infer that the tumor would behave similarly to a grade IV glioblastoma. Update 4 suggested that, in children and young adults, subtypes of IDH\u2010wildtype\/H3\u2010wildtype diffuse gliomas may have distinct clinical features in the setting of a\n                    <jats:italic>BRAF<\/jats:italic>\n                    <jats:sup>V600E<\/jats:sup>\n                    mutation,\n                    <jats:italic>FGFR1<\/jats:italic>\n                    alteration, other MAPK pathway alteration, or a\n                    <jats:italic>MYB<\/jats:italic>\n                    or\n                    <jats:italic>MYBL1<\/jats:italic>\n                    rearrangement. The practical diagnostic relevance of these cIMPACT proposals is highlighted in this summary.\n                  <\/jats:p>","DOI":"10.1111\/bpa.12732","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T22:44:23Z","timestamp":1556664263000},"page":"469-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["cIMPACT\u2010NOW: a practical summary of diagnostic points from Round 1 updates"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-4099","authenticated-orcid":false,"given":"David N.","family":"Louis","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Ellison","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital Memphis TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Brat","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Aldape","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Capper","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Department of Neuropathology Freie Universit\u00e4t Berlin Berlin Germany"},{"name":"Department of Neuropathology Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"},{"name":"Department of Neuropathology Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Paediatric Laboratory Medicine, The Hospital for Sick Children University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Paulus","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology University Hospital Munster Munster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Reifenberger","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Heinrich Heine University Duesseldorf Germany"},{"name":"German Cancer Consortium (DKTK) partner site Essen\/Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Figarella\u2010Branger","sequence":"additional","affiliation":[{"name":"Institut de Neurophysiopathology H\u00f4pital de la Timone, Service d'Anatomie Pathologique et de Neuropathologie, Aix\u2010Marseille Univ, APHM, CNRS Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Institute of Pathology Ruprecht\u2010Karls\u2010University Heidelberg Germany"},{"name":"Clinical Cooperation Unit Neuropathology German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Wesseling","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam University Medical Centers\/VUmc Amsterdam The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1913-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01987-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1646-x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12457"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1826-y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1808-0"}],"container-title":["Brain 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