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An earlier onset of aggregation is obtained upon intracerebral injection of A\u03b2\u2010containing brain homogenate into human APP transgenic mice that follows a prion\u2010like seeding mechanism. Immunoprecipitation of these brain extracts with anti\u2010A\u03b2 oligomer antibodies or passive immunization of the recipient animals abrogated the observed seeding activity, although induced A\u03b2 deposition was still evident. Here, we establish that, together with A\u03b2 monomers, A\u03b2 oligomers trigger the initial phase of A\u03b2 seeding and that the depletion of oligomeric A\u03b2 delays the aggregation process, leading to a transient reduction of seed\u2010induced A\u03b2 deposits. This work extends the current knowledge about the role of A\u03b2 oligomers beyond its cytotoxic nature by pointing to a role in the initiation of A\u03b2 aggregation <jats:italic>in vivo<\/jats:italic>. We conclude that A\u03b2 oligomers are important for the early initiation phase of the seeding process.<\/jats:p>","DOI":"10.1111\/bpa.12734","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T10:29:52Z","timestamp":1558088992000},"page":"36-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["A\u03b2 oligomers trigger and accelerate A\u03b2 seeding"],"prefix":"10.1111","volume":"30","author":[{"given":"Natalie","family":"Katzmarski","sequence":"first","affiliation":[{"name":"Department of Neurology Medical Center \u2013 University of Freiburg Freiburg Germany"},{"name":"Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Faculty of Biology University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Ziegler\u2010Waldkirch","sequence":"additional","affiliation":[{"name":"Department of Neurology 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