{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:52:16Z","timestamp":1790797936764,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["DP5 OD021403"],"award-info":[{"award-number":["DP5 OD021403"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u201cMyxoid glioneuronal tumor, <jats:italic>PDGFRA<\/jats:italic> p.K385\u2010mutant\u201d is a recently described tumor entity of the central nervous system with a predilection for origin in the septum pellucidum and a defining dinucleotide mutation at codon 385 of the <jats:italic>PDGFRA<\/jats:italic> oncogene replacing lysine with either leucine or isoleucine (p.K385L\/I). Clinical outcomes and optimal treatment for this new tumor entity have yet to be defined. Here, we report a comprehensive clinical, radiologic, and histopathologic assessment of eight cases. In addition to its stereotypic location in the septum pellucidum, we identify that this tumor can also occur in the corpus callosum and periventricular white matter of the lateral ventricle. Tumors centered in the septum pellucidum uniformly were associated with obstructive hydrocephalus, whereas tumors centered in the corpus callosum and periventricular white matter did not demonstrate hydrocephalus. While multiple patients were found to have ventricular dissemination or local recurrence\/progression, all patients in this series remain alive at last clinical follow\u2010up despite only biopsy or subtotal resection without adjuvant therapy in most cases. Our study further supports \u201cmyxoid glioneuronal tumor, <jats:italic>PDGFRA<\/jats:italic> p.K385\u2010mutant\u201d as a distinct CNS tumor entity and expands the spectrum of clinicopathologic and radiologic features of this neoplasm.<\/jats:p>","DOI":"10.1111\/bpa.12797","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T13:08:01Z","timestamp":1571058481000},"page":"479-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Myxoid glioneuronal tumor, <i>PDGFRA<\/i> p.K385\u2010mutant: clinical, radiologic, and histopathologic features"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-9592","authenticated-orcid":false,"given":"Calixto\u2010Hope G.","family":"Lucas","sequence":"first","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier E.","family":"Villanueva\u2010Meyer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Whipple","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Department of Pediatrics University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Ann","family":"Oberheim Bush","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurological Surgery University of California San Francisco CA"},{"name":"Department of Neurology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha","family":"Cooney","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Department of Pediatrics University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurological Surgery University of California San Francisco CA"},{"name":"Department of Neurology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Cham","sequence":"additional","affiliation":[{"name":"Department of Pathology UCSF Benioff Children\u2019s Hospital Oakland Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery UCSF Benioff Children\u2019s Hospital Oakland Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Putnam","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bollo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery Department of Neurosurgery University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Cheshier","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery Department of Neurosurgery University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"Poppe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Huntsman Cancer Institute, University of Utah Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar\u2010Ming","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Oklahoma Oklahoma City OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Neurology Stephenson Cancer Center University of Oklahoma Health Sciences Center Oklahoma City OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Glenn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Stephenson Cancer Center University of Oklahoma Health Sciences Center Oklahoma City OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemo","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology Cedars Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serguei","family":"Bannykh","sequence":"additional","affiliation":[{"name":"Department of Pathology Cedars Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jethro","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moise","family":"Danielpour","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cedars Sinai Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Children\u2019s Hospital of Alabama Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Alva","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Department of Pediatrics Children\u2019s Hospital of Alabama Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children\u2019s Hospital of Alabama Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Van Ziffle","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"},{"name":"Clinical Cancer Genomics Laboratory University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Onodera","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"},{"name":"Clinical Cancer Genomics Laboratory University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Devine","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"},{"name":"Clinical Cancer Genomics Laboratory University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Grenert","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"},{"name":"Clinical Cancer Genomics Laboratory University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-4862","authenticated-orcid":false,"given":"Julieann C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Pekmezci","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Tihan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Bollen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-7261","authenticated-orcid":false,"given":"Arie","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"},{"name":"Department of Neurological Surgery University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-7999","authenticated-orcid":false,"given":"David A.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco CA"},{"name":"Clinical Cancer Genomics Laboratory University of California San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.034"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0511-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402121"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199705000-00035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz037"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1135-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12747"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000600"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000080"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02826-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090464"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1819-x"},{"key":"e_1_2_8_15_1","first-page":"699","article-title":"Targeted next\u2010generation sequencing of pediatric neuro\u2010oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy","volume":"19","author":"Kline CN","year":"2017","journal-title":"Neuro\u2010Oncol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0598-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1906-z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.08.017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44448"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1972310"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-1491"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1820-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0551-z"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12639"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1539-z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1549-x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02038-4"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1883-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000255530.46092.AA"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12561"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP300410"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-010-1307-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2611"}],"container-title":["Brain Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbpa.12797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bpa.12797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:01:26Z","timestamp":1693854086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bpa.12797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/bpa.12797"],"URL":"https:\/\/doi.org\/10.1111\/bpa.12797","archive":["Portico"],"relation":{},"ISSN":["1015-6305","1750-3639"],"issn-type":[{"value":"1015-6305","type":"print"},{"value":"1750-3639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,6]]},"assertion":[{"value":"2019-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}