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Five of those seven miRNAs, miR\u2010330\u20103p, miR\u20104286, miR\u20104488, let\u20107e\u20105p, miR\u2010432\u20105p shared the common target synaptotagmin7 (Syt7). Immunohistochemistry and transcript analyses using nanostring technology revealed a maldistribution of Syt7, with Syt7 accumulation in neuronal soma and decreased expression in axonal structures. This maldistribution could be at least partially explained by an axonal Syt7 transport disturbance. Since Syt7 is a synapse\u2010associated molecule, this maldistribution could result in impairment of neuronal functions in MS patients. Thus, our results lead to the hypothesis that the overexpression of these five miRNAs in gray matter lesions is a cellular mechanism to reduce further endogenous neuronal Syt7 production. Therefore, miRNAs seem to play an important role as modulators of neuronal structures in MS.<\/jats:p>","DOI":"10.1111\/bpa.12800","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T12:19:48Z","timestamp":1572437988000},"page":"524-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["MicroRNA profiles of MS gray matter lesions identify modulators of the synaptic protein synaptotagmin\u20107"],"prefix":"10.1111","volume":"30","author":[{"given":"Lena","family":"Fritsche","sequence":"first","affiliation":[{"name":"Institute of Neuropathology University Hospital Essen D\u201045147 Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Teuber\u2010Hanselmann","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology University Hospital Essen D\u201045147 Essen 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