{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:56:59Z","timestamp":1791273419378,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple system atrophy (MSA) and Parkinson's disease (PD) are synucleinopathies characterized by aggregation of \u03b1\u2010synuclein in brain cells. Recent studies have shown that morphological changes in terms of cerebral nerve cell loss and increase in glia cell numbers, the degree of brain atrophy and molecular and epidemiological findings are more severe in MSA than PD. In the present study, we performed a stereological comparison of cerebellar volumes, granule and Purkinje cells in 13 patients diagnosed with MSA [8 MSA\u2010P (striatonigral subtype) and 5 MSA\u2010C (olivopontocerebellar subtype)], 12 PD patients, and 15 age\u2010matched control subjects. Only brains from MSA\u2010C patients showed a reduction in the total number of Purkinje cells (anterior lobe) whereas both MSA\u2010P and MSA\u2010C patients had reduced Purkinje cell volumes (perikaryons and nuclei volume). The cerebellum of both diseases showed a reduction in the white matter volume compared to controls. The number of granule cells was unaffected in both diseases. Analyses of cell type\u2010specific mRNA expression supported our structural data. This study of the cerebellum is in line with previous findings in the cerebrum and demonstrates that the degree of morphological changes is more pronounced in MSA\u2010C than MSA\u2010P and PD. Further, our results support an explicit involvement of cerebellar Purkinje cells and white matter connectivity in MSA\u2010C\u00a0&gt;\u00a0MSA\u2010P and points to the potential importance of white matter alterations in PD pathology.<\/jats:p>","DOI":"10.1111\/bpa.12806","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T09:45:20Z","timestamp":1574761520000},"page":"576-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pathological changes in the cerebellum of patients with multiple system atrophy and Parkinson's disease\u2014a stereological study"],"prefix":"10.1111","volume":"30","author":[{"given":"Elisabeth H. L.","family":"Rusholt","sequence":"first","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience Department of Neurology Bispebjerg\u2010Frederiksberg Hospital Nielsine Nielsens Vej 6B DK\u20102400 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"Salvesen","sequence":"additional","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience Department of Neurology Bispebjerg\u2010Frederiksberg Hospital Nielsine Nielsens Vej 6B DK\u20102400 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Brudek","sequence":"additional","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience Department of Neurology Bispebjerg\u2010Frederiksberg Hospital Nielsine Nielsens Vej 6B DK\u20102400 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betel","family":"Tesfay","sequence":"additional","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience Department of Neurology Bispebjerg\u2010Frederiksberg Hospital Nielsine Nielsens Vej 6B DK\u20102400 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Pakkenberg","sequence":"additional","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience Department of Neurology Bispebjerg\u2010Frederiksberg Hospital Nielsine Nielsens Vej 6B DK\u20102400 Copenhagen Denmark"},{"name":"Institute of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Blegdamsvej 3 DK\u20102200 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-3139","authenticated-orcid":false,"given":"Mikkel V.","family":"Olesen","sequence":"additional","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience Department of Neurology Bispebjerg\u2010Frederiksberg Hospital Nielsine Nielsens Vej 6B DK\u20102400 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2011.01234.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.06.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10884"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-015-0687-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02807.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007758"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq158"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0187-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02661.x"},{"key":"e_1_2_8_11_1","volume-title":"Neuroanatomy: an illustrated colour text","author":"Crossman A","year":"2015"},{"key":"e_1_2_8_12_1","first-page":"117","volume-title":"Brain Imaging in Behavioral Neuroscience","author":"Cumming P","year":"2012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv114"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009258"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23759"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315607"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1988.tb00954.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1987.tb02837.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20537"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1993.tb03321.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20212"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr033"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000310413.04462.6a"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430953"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21992"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(91)90043-7"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12796"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0545-3"},{"key":"e_1_2_8_33_1","first-page":"77","volume-title":"Geriatric psychiatry: a handbook for psychiatrists and primary care physicians","author":"Mattis S","year":"1976"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.12.010"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26979"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv399"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh303"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.1.30"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20877"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl021"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20289"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.07.014"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37116"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.11.008"},{"key":"e_1_2_8_46_1","first-page":"400","article-title":"Neocortical neuronal loss in patients with multiple system atrophy: a stereological study","volume":"27","author":"Salvesen L","year":"2015","journal-title":"Cereb Cortex"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24937"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000209271"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2007.00907.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283480569"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110207"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.037"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws360"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-016-0781-1"}],"container-title":["Brain Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bpa.12806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.12806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:01:15Z","timestamp":1693854075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bpa.12806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/bpa.12806"],"URL":"https:\/\/doi.org\/10.1111\/bpa.12806","archive":["Portico"],"relation":{},"ISSN":["1015-6305","1750-3639"],"issn-type":[{"value":"1015-6305","type":"print"},{"value":"1750-3639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]},"assertion":[{"value":"2018-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}