{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:40:52Z","timestamp":1792485652970,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Advances in our understanding of the biological basis and molecular characteristics of ependymal tumors since the latest iteration of the World Health Organization (WHO) classification of CNS tumors (2016) have prompted the cIMPACT\u2010NOW group to recommend a new classification. Separation of ependymal tumors by anatomic site is an important principle of the new classification and was prompted by methylome profiling data to indicate that molecular groups of ependymal tumors in the posterior fossa and supratentorial and spinal compartments are distinct. Common recurrent genetic or epigenetic alterations found in tumors belonging to the main molecular groups have been used to define tumor types at intracranial sites;\n                    <jats:italic>C11orf95<\/jats:italic>\n                    and\n                    <jats:italic>YAP1<\/jats:italic>\n                    fusion genes for supratentorial tumors and two types of posterior fossa ependymoma defined by methylation group, PFA and PFB. A recently described type of aggressive spinal ependymoma with\n                    <jats:italic>MYCN<\/jats:italic>\n                    amplification has also been included. Myxopapillary ependymoma and subependymoma have been retained as histopathologically defined tumor types, but the classification has dropped the distinction between classic and anaplastic ependymoma. While the cIMPACT\u2010NOW group considered that data to inform assignment of grade to molecularly defined ependymomas are insufficiently mature, it recommends assigning WHO grade 2 to myxopapillary ependymoma and allows grade 2 or grade 3 to be assigned to ependymomas not defined by molecular status.\n                  <\/jats:p>","DOI":"10.1111\/bpa.12866","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T16:49:23Z","timestamp":1591375763000},"page":"863-866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":237,"title":["cIMPACT\u2010NOW update 7: advancing the molecular classification of ependymal tumors"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-7757","authenticated-orcid":false,"given":"David W.","family":"Ellison","sequence":"first","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital 262 Danny Thomas Place Memphis TN 38105 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Aldape","sequence":"additional","affiliation":[{"name":"Center for Cancer Research Laboratory of Pathology National Cancer Institute Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Capper","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Charit\u00e9 Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Fouladi","sequence":"additional","affiliation":[{"name":"Brain Tumor Center Division of Oncology Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Gilbertson","sequence":"additional","affiliation":[{"name":"Department of Oncology Cambridge Cancer Centre Robinson Way Cambridge CB2 0RE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Division of Pathology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology St. Jude Children's Research Hospital 262 Danny Thomas Place MS 210 Memphis TN 38105 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Pajtler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurooncology German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg 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