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Thus, data generated from adult cohorts may be imperfectly suited to guiding diagnostic, prognostic and treatment decisions for children. We studied 50 meningioma patients \u226418\u00a0years with available clinical and pathological data to address the need for data obtained in the pediatric setting. As previously described, we noted a slight bias toward male patients and a higher proportion of spinal tumors compared to adults. Thirty\u2010eight of 50 specimens were further analyzed by next generation sequencing. Loss\u2010of\u2010function mutations in <jats:italic>NF2<\/jats:italic> and chromosome 22 losses were common, but pathogenic variants in other genes (<jats:italic>SMARCB1<\/jats:italic>, <jats:italic>FUBP1<\/jats:italic>, <jats:italic>BRAF<\/jats:italic>, <jats:italic>TERT<\/jats:italic> promoter, <jats:italic>CHEK2<\/jats:italic>, <jats:italic>SMAD<\/jats:italic> and <jats:italic>GATA3<\/jats:italic>) were identified in a minority of cases. Copy number variants outside of chromosomes 22 and 1 were infrequent. H3K27 hypomethylation, a useful biomarker in adult tumors, was not found in our cohort. In exploring the correlation between mitotic count and recurrence\u2010free survival, we found a threshold of six mitoses per 10 high powered fields as the optimal cutoff in predicting recurrence\u2010free survival. If independently validated in larger studies, adjusted grading thresholds could enhance the clinical management of pediatric meningiomas.<\/jats:p>","DOI":"10.1111\/bpa.12884","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T16:02:21Z","timestamp":1595865741000},"page":"1134-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Pediatric meningioma: a clinicopathologic and molecular study with potential grading implications"],"prefix":"10.1111","volume":"30","author":[{"given":"Angus","family":"Toland","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine St. Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-0697","authenticated-orcid":false,"given":"Samantha N.","family":"McNulty","sequence":"additional","affiliation":[{"name":"Department of 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