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They are crucial for brain development and contribute to CNS homeostasis by regulating blood\u2013brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer's disease (AD), implicating this cell type in disease pathology. Here, we have employed state\u2010of\u2010the\u2010art stereological morphometry techniques as well as tissue clearing and two\u2010photon imaging to assess the distribution of pericytes in two independent cohorts of AD (n\u00a0=\u00a016 and 13) and non\u2010demented controls (n\u00a0=\u00a016 and 4). Stereological quantification revealed increased capillary density with a normal pericyte population in the frontal cortex of AD brains, a region with early amyloid \u03b2 deposition. Two\u2010photon analysis of cleared frontal cortex tissue confirmed the preservation of pericytes in AD cases. These results suggest that pericyte demise is not a general hallmark of AD pathology.<\/jats:p>","DOI":"10.1111\/bpa.12897","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T12:58:34Z","timestamp":1599051514000},"page":"1071-1086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Denser brain capillary network with preserved pericytes in Alzheimer's disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Francisco","family":"Fernandez\u2010Klett","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Psychiatry Department of Neuropsychiatry Charit\u00e9 \u2212 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Institute for Pathology Universit\u00e4tsklinik Halle  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Brandt","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Psychiatry 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