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A relationship between LATE\u2010NC and arteriolosclerosis has been reported in some but not all studies. The objectives of this study were to investigate the frequency of co\u2010occurring LATE\u2010NC and microvascular pathologies and test the hypothesis that arteriolosclerosis, specifically, is related to LATE\u2010NC in brains from community\u2010dwelling older persons. Analyses included 749 deceased participants with completed data on LATE\u2010NC and microvascular pathology from 3 longitudinal clinical pathologic studies of aging. Given the specific interest in arteriolosclerosis, we expanded the examination of arteriolosclerosis to include not only the basal ganglia but also two additional white matter regions from anterior and posterior watershed territories. Ordinal logistic regression models examined the association of microvascular pathology with LATE\u2010NC. LATE\u2010NC was present in 409 (54.6%) decedents, of which 354 (86.5%) had one or multiple microvascular pathologies including 132 (32.3%) with moderate\u2010severe arteriolosclerosis in basal ganglia, 195 (47.6%) in anterior watershed, and 144 (35.2%) in posterior watershed; 170 (41.5%) with moderate\u2010severe CAA, and 150 (36.6%) with microinfarcts. In logistic regression models, only posterior watershed arteriolosclerosis, but not other regions of arteriolosclerosis was associated with a higher odds of more advanced LATE\u2010NC stages (Odds Ratio\u00a0=\u00a01.12; 95% Confidence Interval\u00a0=\u00a01.01\u20131.25) after controlling for demographics, AD, and other age\u2010related pathologies. Capillary CAA, but not the severity of CAA was associated with an increased odds of LATE\u2010NC burden (Odds Ratio\u00a0=\u00a01.71; 95% Confidence Interval\u00a0=\u00a01.13\u20132.58). Findings were unchanged in analyses controlling for APOE \u03b54, vascular risk factors, or vascular diseases. These findings suggest that LATE\u2010NC with microvascular pathology is a very common mixed pathology and small vessel disease pathology may contribute to LATE\u2010NC in the aging brain.<\/jats:p>","DOI":"10.1111\/bpa.12939","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T06:53:14Z","timestamp":1614149594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathologic change and microvascular pathologies in community\u2010dwelling older persons"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2375-8888","authenticated-orcid":false,"given":"Sonal","family":"Agrawal","sequence":"first","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL USA"},{"name":"Department of Pathology Rush University Medical Center Chicago IL 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