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Until now, an accurate diagnosis can only be made by <jats:italic>postmortem<\/jats:italic> analysis. Furthermore, the role of \u03b1\u2010syn in A\u03b2 aggregation and the arising characteristic olfactory impairments observed during the progression of these diseases is still not well understood. Therefore, we assessed A\u03b2 load in olfactory bulbs of APP\u2010transgenic mice expressing <jats:italic>APP695<\/jats:italic><jats:sup>KM670\/671NL<\/jats:sup> and <jats:italic>PSEN1<\/jats:italic><jats:sup>L166P<\/jats:sup> under the control of the neuron\u2010specific <jats:italic>Thy\u20101<\/jats:italic> promoter (referred to here as <jats:italic>APPPS1<\/jats:italic>) and <jats:italic>APPPS1<\/jats:italic>\u00a0mice co\u2010expressing <jats:italic>SNCA<\/jats:italic><jats:sup>A30P<\/jats:sup> (referred to here as <jats:italic>APPPS1<\/jats:italic>\u00a0\u00d7\u00a0<jats:italic>[A30P]aSYN<\/jats:italic>). Furthermore, the olfactory capacity of these mice was evaluated in the buried food and olfactory avoidance test. Our results demonstrate an age\u2010dependent increase in A\u03b2 load in the olfactory bulb of APP\u2010transgenic mice that go along with exacerbated olfactory performance. Our study provides clear evidence that the presence of \u03b1\u2010syn significantly diminished the endogenous and seed\u2010induced A\u03b2 deposits and significantly ameliorated olfactory dysfunction in <jats:italic>APPPS1<\/jats:italic>\u00a0\u00d7\u00a0<jats:italic>[A30P]aSYN<\/jats:italic> mice.<\/jats:p>","DOI":"10.1111\/bpa.13032","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T08:16:20Z","timestamp":1635495380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Distinct A\u03b2 pathology in the olfactory bulb and olfactory deficits in a mouse model of A\u03b2 and \u03b1\u2010syn co\u2010pathology"],"prefix":"10.1111","volume":"32","author":[{"given":"Marina","family":"Friesen","sequence":"first","affiliation":[{"name":"Department of Neurology Medical Center University of Freiburg  Freiburg Germany"},{"name":"Faculty of Medicine University of Freiburg  Freiburg 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