{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:22:50Z","timestamp":1782753770898,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI151290"],"award-info":[{"award-number":["R01AI151290"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003061","name":"Erasmus Medisch Centrum","doi-asserted-by":"publisher","award":["Human Disease Model Award 2020"],"award-info":[{"award-number":["Human Disease Model Award 2020"]}],"id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing evidence supports the role of neurotropic herpes simplex virus 1 (HSV\u20101) in the pathogenesis of Alzheimer's disease (AD). However, it is unclear whether previously reported findings in HSV\u20101 cell culture and animal models can be translated to humans. Here, we analyzed clinical specimens from latently HSV\u20101 infected individuals and individuals with lytic HSV infection of the brain (herpes simplex encephalitis; HSE). Latent HSV\u20101 DNA load and latency\u2010associated transcript (LAT) expression were identical between trigeminal ganglia (TG) of AD patients and controls. Amyloid \u03b2 (A\u03b2) and hyperphosphorylated tau (pTau) were not detected in latently HSV\u2010infected TG neurons. Aging\u2010related intraneuronal A\u03b2 accumulations, neurofibrillary tangles (NFT), and\/or extracellular A\u03b2 plaques were observed in the brain of some HSE patients, but these were neither restricted to HSV\u2010infected neurons nor brain regions containing virus\u2010infected cells. Analysis of unique brain material from an AD patient with concurrent HSE showed that HSV\u2010infected cells frequently localized close to A\u03b2 plaques and NFT, but were not associated with exacerbated AD\u2010related pathology. HSE\u2010associated neuroinflammation was not associated with specific A\u03b2 or pTau phenotypes. Collectively, we observed that neither latent nor lytic HSV infection of human neurons is directly associated with aberrant A\u03b2 or pTau protein expression in ganglia and brain.<\/jats:p>","DOI":"10.1111\/bpa.13044","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T08:20:00Z","timestamp":1639642800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["No evidence of aberrant amyloid \u03b2 and phosphorylated tau expression in herpes simplex virus\u2010infected neurons of the trigeminal ganglia and brain"],"prefix":"10.1111","volume":"32","author":[{"given":"Diana N.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Viroscience Erasmus MC University Medical Center Rotterdam  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy T. C. M.","family":"Bakx","sequence":"additional","affiliation":[{"name":"Department of Viroscience Erasmus MC University Medical Center Rotterdam  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"van Dis","sequence":"additional","affiliation":[{"name":"Department of Pathology Erasmus MC University Medical Center Rotterdam  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[{"name":"Department of (Neuro)Pathology Amsterdam Neuroscience Amsterdam University Medical Centers University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Verdijk","sequence":"additional","affiliation":[{"name":"Department of Pathology Erasmus MC University Medical Center Rotterdam  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-296X","authenticated-orcid":false,"given":"Werner J. 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