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The identification of meningioma tumor tissue surrounded by brain tissue in neurosurgical samples has been touted as a criterion for atypical meningioma (CNS WHO grade 2), but is only rarely seen in the absence of other high\u2010grade features, with brain\u2010invasive otherwise benign (BIOB) meningiomas remaining controversial. While post\u2010surgery irradiation therapy might be initiated in brain\u2010invasive meningiomas to prevent recurrences, specific treatment approaches targeting key molecules involved in the invasive process are not established. Here we have compiled the current knowledge about mechanisms supporting brain tissue invasion by meningiomas and summarize preclinical models studying targeted therapies with potential inhibitory effects.<\/jats:p>","DOI":"10.1111\/bpa.13048","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T15:33:33Z","timestamp":1645803213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular neuropathology of brain\u2010invasive meningiomas"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-1711","authenticated-orcid":false,"given":"Niklas","family":"von Spreckelsen","sequence":"first","affiliation":[{"name":"Department of Neuropathology University Hospital Magdeburg  Magdeburg Germany"},{"name":"Department of General Neurosurgery Center for Neurosurgery Cologne University Hospital Faculty of Medicine and University Hospital University of 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