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Synaptic hyperactivity is thought to be because of alteration in the homeostasis of phasic and tonic synaptic inhibition, which is orchestrated by the GABA\n                    <jats:sub>A<\/jats:sub>\n                    inhibitory system, encompassing subclasses of interneurons and GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors, which play a vital role in cognitive functions, including learning and memory. Furthermore, the extracellular matrix, the perineuronal nets (PNNs) which often go unnoticed in considerations of AD pathology, encapsulate the inhibitory cells and neurites in critical brain regions and have recently come under the light for their crucial role in synaptic stabilisation and excitatory\u2010inhibitory balance and when disrupted, serve as a potential trigger for AD\u2010associated synaptic imbalance. Therefore, in this review, we summarise the current understanding of the selective vulnerability of distinct interneuron subtypes, their synaptic and extrasynaptic GABA\n                    <jats:sub>A<\/jats:sub>\n                    R subtypes as well as the changes in PNNs in AD, detailing their contribution to the mechanisms of disease development. We aim to highlight how seemingly unique malfunction in each component of the interneuronal GABA inhibitory system can be tied together to result in critical circuit dysfunction, leading to the irreversible symptomatic damage observed in AD.\n                  <\/jats:p>","DOI":"10.1111\/bpa.13129","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T09:05:25Z","timestamp":1669021525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["The fate of interneurons,\n                    <scp>\n                      GABA\n                      <sub>A<\/sub>\n                    <\/scp>\n                    receptor sub\u2010types and perineuronal nets in Alzheimer's disease"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-5609","authenticated-orcid":false,"given":"Afia B.","family":"Ali","sequence":"first","affiliation":[{"name":"UCL School of 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