{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:17:04Z","timestamp":1792891024189,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["70112956"],"award-info":[{"award-number":["70112956"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003493","name":"Gemeinn\u00fctzige Hertie\u2010Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Risk prediction for meningioma tumors was until recently almost exclusively based on morphological features of the tumor. To improve risk prediction, multiple models have been established that incorporate morphological and molecular features for an integrated risk prediction score. One such model is the integrated molecular\u2010morphologic meningioma integrated score (IntS), which allocates points to the histological grade, epigenetic methylation family and specific copy\u2010number variations. After publication of the IntS, questions arose in the neuropathological community about the practical and clinical implementation of the IntS, specifically regarding the calling of CNVs, the applicability of the newly available version (v12.5) of the brain tumor classifier and the need for incorporation of\n                    <jats:italic>TERT<\/jats:italic>\n                    \u2010promoter and\n                    <jats:italic>CDKN2A\/B<\/jats:italic>\n                    status analysis in the IntS calculation. To investigate and validate these questions additional analyses of the discovery (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0514), retrospective validation (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0184) and prospective validation (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0287) cohorts used for IntS discovery and validation were performed. Our findings suggest that any loss over 5% of the chromosomal arm suffices for the calling of a CNV, that input from the v12.5 classifier is as good or better than the dedicated meningioma classifier (v2.4) and that there is most likely no need for additional testing for\n                    <jats:italic>TERT<\/jats:italic>\n                    \u2010promoter mutations and\/or homozygous losses of\n                    <jats:italic>CDKN2A\/B<\/jats:italic>\n                    when defining the IntS for an individual patient. The findings from this study help facilitate the clinical implementation of IntS\u2010based risk prediction for meningioma patients.\n                  <\/jats:p>","DOI":"10.1111\/bpa.13132","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T01:51:26Z","timestamp":1668477086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Clinical implementation of integrated molecular\u2010morphologic risk prediction for meningioma"],"prefix":"10.1111","volume":"33","author":[{"given":"Thomas","family":"Hielscher","sequence":"first","affiliation":[{"name":"Department of Biostatistics German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sill","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center Heidelberg (KiTZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Sievers","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Hospital Heidelberg and CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK) German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Stichel","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Hospital Heidelberg and CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK) German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-0342","authenticated-orcid":false,"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, National Hospital for Neurology and Neurosurgery University College London NHS Foundation Trust  London UK"},{"name":"Department of Neurodegenerative Disease, Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T. W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center Heidelberg (KiTZ)  Heidelberg Germany"},{"name":"Division of Pediatric Glioma Research German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Hospital Heidelberg and CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK) German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Sahm","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Hospital Heidelberg and CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK) German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-4405","authenticated-orcid":false,"given":"Sybren L. N.","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Pathology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Pathology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab200"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv377"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02188-w"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30155-9"},{"key":"e_1_2_12_7_1","first-page":"1","article-title":"A molecularly integrated grade for meningioma","volume":"24","author":"Driver J","year":"2021","journal-title":"Neuro\u2010Oncology"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00784"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxp011"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6370"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-6-64"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.6.628"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.156"},{"key":"e_1_2_12_15_1","unstructured":"Volker HovestadtMZ.conumee. 2017.https:\/\/doi.org\/10.18129\/B9.BIOC.CONUMEE."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02247-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.JTN.27546-19.2"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz061"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03850-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01061-8"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02415-6"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1837-8"}],"container-title":["Brain Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.13132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bpa.13132","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.13132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:45:22Z","timestamp":1692643522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bpa.13132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/bpa.13132"],"URL":"https:\/\/doi.org\/10.1111\/bpa.13132","archive":["Portico"],"relation":{},"ISSN":["1015-6305","1750-3639"],"issn-type":[{"value":"1015-6305","type":"print"},{"value":"1750-3639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,14]]},"assertion":[{"value":"2022-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13132"}}