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In this study, we found that ablation of genes encoding ciliary transport proteins such as intraflagellar transport homolog 88 (Ift88) and kinesin family member 3a (Kif3a) in cortical radial progenitors led to periventricular heterotopia during late mouse embryogenesis. Conditional mutation of primary cilia unexpectedly caused breakdown of both the neuroepithelial lining and the blood\u2010choroid plexus barrier. Choroidal leakage was partially caused by enlargement of the choroid plexus in the cilia mutants. We found that the choroid plexus expressed platelet\u2010derived growth factor A (Pdgf\u2010A) and that Pdgf\u2010A expression was ectopically increased in cilia\u2010mutant embryos. Cortices obtained from embryos in utero electroporated with <jats:italic>Pdgfa<\/jats:italic> mimicked periventricular heterotopic nodules of the cilia mutant. 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