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Mutations in <jats:italic>Klf7<\/jats:italic> are associated with autism spectrum disorder, which is characterized by neurodevelopmental delay and intellectual disability. Here we show that KLF7 regulates neurogenesis and neuronal migration during mouse cortical development. Conditional depletion of KLF7 in neural progenitor cells resulted in agenesis of the corpus callosum, defects in neurogenesis, and impaired neuronal migration in the neocortex. Transcriptomic profiling analysis indicated that KLF7 regulates a cohort of genes involved in neuronal differentiation and migration, including <jats:italic>p21<\/jats:italic> and <jats:italic>Rac3<\/jats:italic>. These findings provide insights into our understanding of the potential mechanisms underlying neurological defects associated with <jats:italic>Klf7<\/jats:italic> mutations.<\/jats:p>","DOI":"10.1111\/bpa.13186","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T05:34:18Z","timestamp":1688448858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Kr\u00fcppel\u2010like factor 7 deficiency disrupts corpus callosum development and neuronal migration in the developing mouse cerebral cortex"],"prefix":"10.1111","volume":"33","author":[{"given":"Wentong","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pifang","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Anatomy, 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