{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:33:25Z","timestamp":1787686405001,"version":"build-2784847793"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the molecular spectrum of amyloid\u2010beta (A\u03b2) in neurodegenerative diseases beyond Alzheimer's disease (AD). We analyzed A\u03b2 deposition in the temporal cortex and striatum in 116 autopsies, including Lewy body disease (LBD; <jats:italic>N<\/jats:italic>\u2009=\u200951), multiple system atrophy (MSA; <jats:italic>N<\/jats:italic>\u2009=\u200910), frontotemporal lobar degeneration\u2010TDP\u201043 (FTLD\u2010TDP; <jats:italic>N<\/jats:italic>\u2009=\u200916), and progressive supranuclear palsy (PSP; <jats:italic>N<\/jats:italic>\u2009=\u200939). The LBD group exhibited the most A\u03b2 deposition in the temporal cortex and striatum (90\/76%, respectively), followed by PSP (69\/28%), FTLD\u2010TDP (50\/25%), and the MSA group (50\/10%). We conducted immunohistochemical analysis using antibodies targeting eight A\u03b2 epitopes in the LBD and PSP groups. Immunohistochemical findings were evaluated semi\u2010quantitatively and quantitatively using digital pathology. Females with LBD exhibited significantly more severe A\u03b2 deposition, particularly A\u03b2<jats:sub>42<\/jats:sub> and A\u03b2<jats:sub>43<\/jats:sub>, along with significantly more severe tau pathology. Furthermore, a quantitative analysis of all A\u03b2 peptides in the LBD group revealed an association with the <jats:italic>APOE\u2010<\/jats:italic>\u03b54 genotypes. No significant differences were observed between males and females in the PSP group. Finally, we compared striatal A\u03b2 deposition in cases with LBD (<jats:italic>N<\/jats:italic>\u2009=\u200915), AD without \u03b1\u2010synuclein pathology (<jats:italic>N<\/jats:italic>\u2009=\u20096), and PSP (<jats:italic>N<\/jats:italic>\u2009=\u20095). There were no differences in the pan\u2010A\u03b2 antibody (6F\/3D)\u2010immunolabeled deposition burden among the three groups, but the deposition burden of peptides with high aggregation capacity, especially A\u03b2<jats:sub>43<\/jats:sub>, was significantly higher in the AD and LBD groups than in the PSP group. Furthermore, considerable heterogeneity was observed in the composition of A\u03b2 peptides on a case\u2010by\u2010case basis in the AD and LBD groups, whereas it was relatively uniform in the PSP group. Cluster analysis further supported these findings. Our data suggest that the type of concomitant proteinopathies influences the spectrum of A\u03b2 deposition, impacted also by sex and <jats:italic>APOE<\/jats:italic> genotypes.<\/jats:p>","DOI":"10.1111\/bpa.13210","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:37:12Z","timestamp":1693528632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The molecular spectrum of amyloid\u2010beta (A\u03b2) in neurodegenerative diseases beyond Alzheimer's disease"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-8137","authenticated-orcid":false,"given":"Shojiro","family":"Ichimata","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Disease University of Toronto  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario 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