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However, multiple copathologies can be observed in the AD brain and contribute to the development of cognitive decline. Limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathological changes (LATE\u2010NC) accumulates in the majority of AD cases and leads to more severe cognitive decline compared with AD pathology alone. In this review, we focus on the synergistic relationship between LATE\u2010NC and tau in AD, highlighting the aggravating role of TDP\u201043 aggregates on tau pathogenesis and its impact on the clinical picture and therapeutic strategies. Additionally, we discuss to what extent the molecular patterns of LATE\u2010NC in AD differ from frontotemporal lobar degeneration with TDP\u201043 pathology (FTLD\u2010TDP) neuropathological changes. Thus, we highlight the importance of tau and TDP\u201043 synergies for subtyping AD patients, which may respond differently to therapeutic interventions depending on the presence of comorbid LATE\u2010NC.<\/jats:p>","DOI":"10.1111\/bpa.13213","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:58:07Z","timestamp":1696517887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp>LATE\u2010NC<\/scp>\n                    in\n                    <scp>Alzheimer's<\/scp>\n                    disease:\n                    <scp>Molecular<\/scp>\n                    aspects and synergies"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5253-0730","authenticated-orcid":false,"given":"Sandra O.","family":"Tom\u00e9","sequence":"first","affiliation":[{"name":"Laboratory for Neuropathology, Department of Imaging and Pathology and Leuven Brain 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