{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:28:19Z","timestamp":1793665699428,"version":"4.5.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Meningeal solitary fibrous tumors (SFT) are rare and have a high frequency of local recurrence and distant metastasis. In a cohort of 126 patients (57 female, 69 male; mean age at surgery 53.0\u2009years) with pathologically confirmed meningeal SFTs with extended clinical follow\u2010up (median 9.9\u2009years; range 15\u2009days\u201343\u2009years), we performed extensive molecular characterization including genome\u2010wide DNA methylation profiling (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200980) and targeted\n                    <jats:italic>TERT<\/jats:italic>\n                    promoter mutation testing (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200998). Associations were examined with\n                    <jats:italic>NAB2::STAT6<\/jats:italic>\n                    fusion status (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009101 cases; 51\u2009=\u2009ex5\u20107::ex16\u201017, 26\u2009=\u2009ex4::ex2\u20103; 12\u2009=\u2009ex2\u20103::exANY\/other and 12\u2009=\u2009no fusion) and placed in the context of 2021 Central Nervous System (CNS) WHO grade.\n                    <jats:italic>NAB2::STAT6<\/jats:italic>\n                    fusion breakpoints (fusion type) were significantly associated with metastasis\u2010free survival (MFS) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) and, on multivariate analysis, disease\u2010specific survival (DSS) when adjusting for CNS WHO grade (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). DNA methylation profiling revealed three distinct clusters: Cluster 1 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200938), Cluster 2 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922), and Cluster 3 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920). Methylation clusters were significantly associated with fusion type (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with Cluster 2 harboring ex4::ex2\u20103 fusion in 16 (of 20; 80.0%), nearly all\n                    <jats:italic>TERT<\/jats:italic>\n                    promoter mutations (7 of 8; 87.5%), and predominantly an \u201cSFT\u201d histologic phenotype (15 of 22; 68.2%). Clusters 1 and 3 were less distinct, both dominated by tumors having ex5\u20107::ex16\u201017 fusion (respectively, 25 of 33; 75.8%, and 12 of 18; 66.7%) and with variable histological phenotypes. Methylation clusters were significantly associated with MFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027), but not overall survival (OS). In summary,\n                    <jats:italic>NAB2::STAT6<\/jats:italic>\n                    fusion type was significantly associated with MFS and DSS, suggesting that tumors with an ex5::ex16\u201017 fusion may have inferior patient outcomes. Methylation clusters were significantly associated with fusion type,\n                    <jats:italic>TERT<\/jats:italic>\n                    promoter mutation status, histologic phenotype, and MFS.\n                  <\/jats:p>","DOI":"10.1111\/bpa.13256","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:29:59Z","timestamp":1711326599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>NAB2::STAT6<\/i>\n                    fusions and genome\u2010wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-2723","authenticated-orcid":false,"given":"Kathryn L.","family":"Eschbacher","sequence":"first","affiliation":[{"name":"University of Iowa Hospitals &amp; Clinics IA  Iowa City Iowa 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