{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:33Z","timestamp":1791925713738,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_212322"],"award-info":[{"award-number":["310030_212322"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early diagnosis of late\u2010onset Alzheimer's disease (AD) by peripheral biomarkers remains a challenge; many have been proposed, but none have been evaluated in a prospective manner. CLUSTERIN (CLU), a chaperone protein expressed in the brain and found in relatively high concentrations in plasma, is a promising candidate. CLU contributes to the elimination of \u03b2\u2010amyloid (A\u03b2), which is associated to neurofibrillary tangles and to the genetic risk for AD. We performed a longitudinal measurement of CLU in the brain and the plasma in 3xTgAD mice. Assessment of CLU was also conducted in 12\u2010month\u2010old TgF344\u2010AD rats. In humans, brain CLU was measured in non\u2010demented and in AD subjects. The plasma CLU was longitudinally measured in four cohorts defined as healthy controls that remained stable, healthy controls that presented a cognitive decline between the two measures, mild cognitive impairment (MCI) that presented a cognitive decline between the two measures and AD. A validation cohort composed of 19 MCI was used and plasma CLU was measured before and after conversion in AD. Increases in CLU were measured in the hippocampus of 3xTgAD and TgF344\u2010AD animals in the absence of plasmatic changes. CLU is heterogeneously expressed in the hippocampus in non\u2010demented individuals and increased in AD. In the plasma, two CLU levels were measured: low in controls and MCI, and high in AD. To validate that the elevation in CLU is associated with conversion to AD, a replication study showed, in a second group MCI patients converting to AD in the follow\u2010up that CLU levels increased in 16\/19 individuals. The increase in brain CLU occurs in AD models as in humans, and seems to precede plasma variations, which could make it an AD therapeutic target. Plasma CLU seems to be a promising marker of cognitive decline, and its association with AD may be a useful complementary diagnostic tool.<\/jats:p>","DOI":"10.1111\/bpa.13281","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T06:00:12Z","timestamp":1719036012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Brain and plasmatic\n                    <scp>CLUSTERIN<\/scp>\n                    are translational markers of\n                    <scp>Alzheimer's<\/scp>\n                    disease"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8027-7530","authenticated-orcid":false,"given":"Benjamin B.","family":"Tournier","sequence":"first","affiliation":[{"name":"Department of Psychiatry University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Ceyz\u00e9riat","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospitals of Geneva and University of Geneva  Geneva Switzerland"},{"name":"CIBM Center for BioMedical Imaging, Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Laboratory of Child Growth and Development University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Marteyn","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine for the Aged University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5553-9594","authenticated-orcid":false,"given":"Quentin","family":"Amoss\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien M.","family":"Badina","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios","family":"Tsartsalis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois R.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and rehabilitation University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Zekry","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine for the Aged University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Millet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospitals of Geneva and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0311-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202100287"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00850-X"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600419"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1291"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00416-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00426-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12660"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701137114"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166384"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0319-x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr101221h"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.10.014"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"53","article-title":"Practical detection of a definitive biomarker panel for Alzheimer's disease; 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