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In this article the basic biological characteristics of SST are briefly reviewed, and focus given to the immunohistochemical evaluation of SST2 and SST5 in growth hormone (GH)\u2010secreting pituitary tumors, and their quantification as predictors of response to treatment with somatostatin receptor ligands (SRL), the mainstay of the pharmacological therapy available for these tumors. Although many different scoring systems for SST2 immunohistochemistry showing correlation with SRL response have been reported, among which the immunoreactivity score (IRS) has been the most consistently used, a universally validated immunohistochemical technique and scoring scheme is lacking. Efforts should be made on collaborative multicenter studies aiming at validating homogeneous immunostaining protocols and a scoring system for SST2 and SST5 expression, to help clinicians to define the optimal therapeutic strategy for the patients with somatotroph tumors.<\/jats:p>","DOI":"10.1111\/bpa.13313","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T06:32:59Z","timestamp":1730269979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Somatostatin receptors in pituitary somatotroph adenomas as predictors of response to somatostatin receptor ligands: A pathologist's perspective"],"prefix":"10.1111","volume":"35","author":[{"given":"Laura","family":"Botelho","sequence":"first","affiliation":[{"name":"Neuropathology and Molecular Genetics Laboratory Instituto Estadual do C\u00e9rebro Paulo Niemeyer  Rio de Janeiro Brazil"},{"name":"Department of Pathology Rede D'Or  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Sperduto","family":"Dezonne","sequence":"additional","affiliation":[{"name":"Neuropathology and Molecular Genetics Laboratory Instituto Estadual do C\u00e9rebro Paulo Niemeyer  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Eduardo","family":"Wildemberg","sequence":"additional","affiliation":[{"name":"Neuroendocrinology Research Center, Endocrinology Division Medical School and Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Neuroendocrinology Division Instituto Estadual do C\u00e9rebro Paulo Niemeyer  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan Lyra","family":"Miranda","sequence":"additional","affiliation":[{"name":"Neuropathology and Molecular Genetics Laboratory Instituto Estadual do C\u00e9rebro Paulo Niemeyer  Rio de 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