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Depending on the direction of hemispheric asymmetry, the associated clinical features include word comprehension impairment, associative agnosia, and behavioral abnormalities. Current research on TDP\u2010C aims to explore the factors that underlie the selective targeting of the ATL and, more specifically, the cellular details that undermine the behavioral and cognitive functions of this region. Abnormal TDP\u2010C neurites have recently been shown to represent heterodimers with annexin A11 (ANXA11). This feature, not shared by TDP\u2010A or \u2010B, may explain the unique predilection of TDP\u2010C for the ATL. To further explore the subcellular distribution of the pathology, paraffin\u2010embedded sections were stained using fluorescent antibodies for the dendritic marker MAP2 and phosphorylated TDP\u201043 (pTDP) or ANXA11. Results indicated that approximately half of pTDP\/ANXA11 neurites co\u2010localized with MAP2. The actual overlap during life may be much higher but decreased at autopsy through dendritic loss due to prolonged neurodegeneration. The potentially selective and progressive dendritic pathology of TDP\u2010C, quite unique among neurodegenerative entities, may underlie the distinctive perturbation of cortical integrative computations.<\/jats:p>","DOI":"10.1111\/bpa.70032","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T02:09:50Z","timestamp":1753322990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dendritic location of dystrophic neurites in\n                    <scp>FTLD<\/scp>\n                    \u2010\n                    <scp>TDP<\/scp>\n                    type C with annexinopathy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-5350","authenticated-orcid":false,"given":"Allegra","family":"Kawles","sequence":"first","affiliation":[{"name":"Mesulam Institute for Cognitive Neurology and Alzheimer's Disease Northwestern University Feinberg School of 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