{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:31:45Z","timestamp":1782815505704,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The 14\u20103\u20103 protein family plays a crucial role in cellular signaling and neuronal survival. Although 14\u20103\u20103 isoforms have been involved in the etiology of some neurodegenerative disorders, their role remains poorly understood in alpha\u2010synucleinopathies. In this study, we wanted to characterize 14\u20103\u20103 gene expression patterns in the brain and periphery of patients with Lewy body pathology (LBP). We analyzed messenger RNA (mRNA) expression of all seven 14\u20103\u20103 isotypes in the temporal cortex and caudate nucleus of brains with pure and common LBP, as well as in cerebrospinal fluid, peripheral blood, and platelets. Stratifin (SFN) protein expression was assessed by immunohistochemistry and enzyme\u2010linked immunosorbent assay. Effects of SFN overexpression on astrocyte activation were investigated in vitro. In the temporal cortex of LBP patients, six out of seven 14\u20103\u20103 genes were significantly downregulated, while SFN was markedly up\u2010regulated. SFN protein localized to neurofibrillary tangles in the parahippocampal region and reactive astrocytes in white matter. In vitro, SFN treatment induced biphasic changes in astrocytic glial fibrillary acidic protein expression, suggesting a role in glial activation. Peripheral analysis revealed no significant 14\u20103\u20103 mRNA changes in blood, but platelet expression patterns inversely correlated with brain tissue; six isoforms were up\u2010regulated, and SFN was strongly downregulated in dementia with Lewy bodies (DLB) platelets. Our findings revealed an important shift in 14\u20103\u20103 isotype expression in the temporal cortex of LBP patients, where SFN up\u2010regulation reflected its colocalization with tau pathology and astrocytic reactivity. The inverse expression profile in platelets in DLB highlights their potential as accessible biomarkers for molecular changes occurring in the brain.<\/jats:p>","DOI":"10.1111\/bpa.70059","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T01:50:12Z","timestamp":1765936212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["14\u20103\u20103\u03c3 up\u2010regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-1656","authenticated-orcid":false,"given":"Laura","family":"Marsal\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Neuroscience Health Sciences Research Institute Germans Trias i Pujol  Badalona Spain"},{"name":"Department of Biochemistry, Goodman Cancer Institute McGill University  Montreal 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