{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:27:00Z","timestamp":1782509220960,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1C1C1011427"],"award-info":[{"award-number":["2021R1C1C1011427"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000508681"],"award-info":[{"award-number":["RS\u20102024\u201000508681"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["GLT\u201025071\u2010100"],"award-info":[{"award-number":["GLT\u201025071\u2010100"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018749","name":"Korea Brain Research Institute","doi-asserted-by":"publisher","award":["25\u2010BR\u201002\u201003"],"award-info":[{"award-number":["25\u2010BR\u201002\u201003"]}],"id":[{"id":"10.13039\/100018749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018749","name":"Korea Brain Research Institute","doi-asserted-by":"publisher","award":["25\u2010BR\u201008\u201001"],"award-info":[{"award-number":["25\u2010BR\u201008\u201001"]}],"id":[{"id":"10.13039\/100018749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020206","name":"Korea Dementia Research Center","doi-asserted-by":"publisher","award":["RS\u20102023\u2010KH135534"],"award-info":[{"award-number":["RS\u20102023\u2010KH135534"]}],"id":[{"id":"10.13039\/100020206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020206","name":"Korea Dementia Research Center","doi-asserted-by":"publisher","award":["RS\u20102023\u2010KH\u2010138465"],"award-info":[{"award-number":["RS\u20102023\u2010KH\u2010138465"]}],"id":[{"id":"10.13039\/100020206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amyloid\u2010\u03b2 (A\u03b2) plaque is the defining pathological feature of Alzheimer's disease (AD) and a target of various therapeutic agents for affected patients. Recent studies have demonstrated the dysfunction of the blood\u2013brain barrier (BBB) in AD; however, how A\u03b2 plaque induces BBB dysfunction, particularly in brain endothelial cells (ECs), remains elusive. This study investigates the lipid peroxidation\u2010mediated ferroptosis pathway induced by A\u03b2 via conducting RNA sequencing, phosphorylation analysis, metabolite analysis, western blotting, and immunofluorescent staining both in vitro and in vivo. Here, we demonstrate that A\u03b2 is associated with lipid metabolic pathways following A\u03b2 exposure in brain ECs. Additionally, A\u03b2 aggregates induce the formation and accumulation of peroxidized lipid droplets. Lastly, A\u03b2 is significantly reduced in brain ECs and 5xFAD mice by the inhibition of the lipid metabolic pathway associated with lipid peroxidation and ROS formation. Our findings from in vitro and in vivo both suggest that A\u03b2 plays a causative role in the process of lipid peroxidation and might provide a potential target for the development of therapeutic interventions for AD.<\/jats:p>","DOI":"10.1111\/bpa.70074","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:58:33Z","timestamp":1772999913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Amyloid\u2010\u03b2 aggregates induce vasculopathy via ferroptosis in brain endothelial cells"],"prefix":"10.1111","volume":"36","author":[{"given":"Suhyeon","family":"Son","sequence":"first","affiliation":[{"name":"Dementia Research Group Korea Brain Research Institute  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suji","family":"Kim","sequence":"additional","affiliation":[{"name":"Dementia Research Group Korea Brain Research Institute  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Tae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Dementia Research Group Korea Brain Research Institute  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonseok","family":"Choi","sequence":"additional","affiliation":[{"name":"Dementia Research Group Korea Brain Research Institute  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Dementia Research Group Korea Brain Research Institute  Daegu Republic of Korea"},{"name":"Daegu Gyeongbuk Institute of Science and Technology  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suji","family":"Lee","sequence":"additional","affiliation":[{"name":"Dementia Research Group Korea Brain Research Institute  Daegu Republic of Korea"},{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology &amp; Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Yeol","family":"Nah","sequence":"additional","affiliation":[{"name":"Ginsentology Research Laboratory and Department of Physiology College of Veterinary Medicine, Konkuk University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0066-884X","authenticated-orcid":false,"given":"Do\u2010Geun","family":"Kim","sequence":"additional","affiliation":[{"name":"Dementia Research Group Korea Brain Research Institute  Daegu Republic of Korea"},{"name":"Daegu Gyeongbuk Institute of Science and Technology  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/795375"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102677"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00226-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.12.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3050"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147710"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1154641"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.188"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400408"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00434.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.695479"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10030184"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S382643"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx137"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4406"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7760"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07152-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04054-3"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.983623"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9600-5"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00340-2"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.655183"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111556"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206171109"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180173"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1227493"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.12.014"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.01019"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.07.019"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00742"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-012-2025-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.02.014"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0521-7"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5080843"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.10.014"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M013003"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105721"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38725-w"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41048-019-0091-5"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00467"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2018.05.002"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030986"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb5398"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.036"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.049"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010118"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70926-1"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.680090"},{"key":"e_1_2_11_52_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang F","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1047778"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.10.011"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.07.054"},{"issue":"6","key":"e_1_2_11_56_1","article-title":"Screening, assessment, and pharmacologic treatment of mild cognitive impairment and early Alzheimer's disease: the role for monoclonal antibodies","volume":"25","author":"Weinberg MS","year":"2023","journal-title":"Prim Care Companion CNS Disord"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00402.x"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00278"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.07.014"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.01.008"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.32"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0085-z"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.746749"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5099"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcrp.2022.200143"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14070879"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214506"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2007.04.001"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010075"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.095"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz369"}],"container-title":["Brain Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.70074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bpa.70074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bpa.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:34:52Z","timestamp":1780472092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bpa.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/bpa.70074"],"URL":"https:\/\/doi.org\/10.1111\/bpa.70074","archive":["Portico"],"relation":{},"ISSN":["1015-6305","1750-3639"],"issn-type":[{"value":"1015-6305","type":"print"},{"value":"1750-3639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2025-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70074"}}