{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:46:10Z","timestamp":1785717970515,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transmembrane protein 106B (TMEM106B) is a lysosomal glycoprotein whose genetic polymorphisms contribute to the severity of neurodegenerative disorders associated with TDP\u201043 pathology. Recent studies have revealed that TMEM106B can form amyloid filaments composed of C\u2010terminal fragments (CTFs) in the human brain. In the present study, we explored the relationships between TMEM106B, age, TDP\u201043, and tau aggregates, and their roles in neurodegeneration. We used immunohistochemistry with an antibody against CTFs of TMEM106B on postmortem human brain fragments (amygdala, hippocampus, temporal cortex, frontal cortex, and basal ganglia) from patients with and without TDP\u201043\/tau pathology at different ages (6\u201394\u2009years) and with different neurological conditions (subacute sclerosing panencephalitis, Alzheimer's disease, frontotemporal lobar degeneration, and neurologically healthy subjects). Our results revealed that TMEM106B CTF fibrillization is a common, nonspecific, diffuse, and age\u2010dependent phenomenon (appearing after &gt;52\u2009years of age) that affects neurons and neuroglia (most numerous in astrocytes and oligodendrocytes) and broad neuroanatomical regions (most severe in the temporal cortex). We did not find TMEM106B CTF aggregates in young subjects with TDP\u201043\/tau pathology (with subacute sclerosing panencephalitis), but we revealed differences in TMEM106B CTF fibrillization between Alzheimer's disease without TDP\u201043 pathology, frontotemporal lobar degeneration with TDP\u201043 pathology, and older healthy subjects without TDP\u201043\/tau pathology. Our results suggest that TMEM106B CTF aggregation is an age\u2010dependent phenomenon and may have a weak association with TDP\u201043 or tau pathology, shedding new light on the complex relationships among TMEM106B, TDP\u201043, and tau and the unclear role of TMEM106B fibril formation in the neurodegeneration process.<\/jats:p>","DOI":"10.1111\/bpa.70090","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:24:55Z","timestamp":1775543095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between\n                    <scp>TMEM106B<\/scp>\n                    C\u2010terminal fragment aggregation, age, and\n                    <scp>TDP<\/scp>\n                    \u201043 or tau pathology"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-6966","authenticated-orcid":false,"given":"Albert","family":"Acewicz","sequence":"first","affiliation":[{"name":"Department of Neuropathology Institute of Psychiatry and Neurology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Tarka","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Grzegorczyk","sequence":"additional","affiliation":[{"name":"Department of Descriptive and Clinical Anatomy Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-6261","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Rzepli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Descriptive and Clinical Anatomy Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Wierzba\u2010Bobrowicz","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute of Psychiatry and Neurology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"St\u0119pie\u0144","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute of Psychiatry and Neurology  Warsaw 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