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Wasteosomes localize around periventricular (PV) regions, perivascular spaces (PVS), and sub\u2010pial regions; and their accumulation has been found to correlate with aging, vascular disorders, neurodegenerative diseases, and conditions that impair sleep. White matter hyperintensities (WMHs) are diffuse hyperintense areas seen on T2\u2010weighted or fluid\u2010attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans that represent damage to white matter. PV WMHs are known predictors of mild cognitive impairment, stroke, dementia and death. The relationship between wasteosome accumulation, PV WMHs, vascular pathology and PVS is currently unknown. For the first time, in a mixed diagnostic cohort of pathologically diagnosed: Alzheimer's disease (AD), cerebrovascular disease (CVD), mixed AD\/CVD, and control tissue with no pathological diagnosis, we connected the histopathological wasteosome profile in periventricular brain sections in relation to 7T FLAIR\u2010MRI confirmed PV WMHs, vascular sclerosis and PVS. Our results reveal wasteosomes accumulate in PV WMHs, are increased in proximity to large PV venules, and exhibit complex relationships with WMH severity, mixed pathology, sclerotic index and PVS. These findings provide novel insights into the pathophysiology underlying white matter injury.<\/jats:p>","DOI":"10.1111\/bpa.70110","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:01:48Z","timestamp":1779285708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space"],"prefix":"10.1111","volume":"36","author":[{"given":"Nikita","family":"Ollen\u2010Bittle","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Boesgaard","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Schulich 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