{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:43:55Z","timestamp":1782960235831,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016950","name":"Thompson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["HU00012120007"],"award-info":[{"award-number":["HU00012120007"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","award":["312159\u20101.00\u201066531"],"award-info":[{"award-number":["312159\u20101.00\u201066531"]}],"id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We recently reported the deposition of A\u03b2 in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID\u201019), or who did not have COVID\u201019 but had respiratory distress, or infants with severe cardiac malformations. These A\u03b2 deposits were not the senile, neuritic core \u201cplaques\u201d of Alzheimer's disease (AD) and did not stain for Thioflavin\u2010S or with antibodies to phosphorylated tau protein. Here, we examined multiple sections of the brains of such individuals, finding these non\u2010Alzheimer A\u03b2 deposits (NADAs) predominantly in the isocortex, including frontal, temporal, insular, and occipital, but also in subcortical structures such as the diencephalon, cerebellum, brainstem, and spinal cord, albeit many fewer. NADAs also appeared around blood vessels and within blood vessel walls, but did not incite an inflammatory response. We also examined brains of individuals with metabolic and mitochondrial diseases that lead to hypoxic damage and one individual with severe hyperthermia. All had NADAs identical to the ones we previously reported. These A\u03b2 deposits somewhat resemble the amorphous or diffuse plaques or deposits that have been thought to be associated with early stages of AD, but they are morphologically distinguishable and appear in brains of young individuals who have no Alzheimer pathology. We suggest that the deposits are associated with hypoxia or related mechanisms of injury.<\/jats:p>","DOI":"10.1111\/bpa.70120","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:00:26Z","timestamp":1782957626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Alzheimer A\u03b2 deposits in the human\n                    <scp>CNS<\/scp>\n                    : Implications with hypoxia and related conditions"],"prefix":"10.1111","author":[{"given":"Esma","family":"Karlovich","sequence":"first","affiliation":[{"name":"Division of Neuropathology, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center, and the New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Priemer","sequence":"additional","affiliation":[{"name":"Department of Defense\/Uniformed Services University Brain Tissue Repository F. Edward Hebert School of Medicine  Bethesda Maryland USA"},{"name":"Department of Pathology Uniformed Services University, F. Edward Hebert School of Medicine  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Harker","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Department of Defense\/Uniformed Services University Brain Tissue Repository F. Edward Hebert School of Medicine  Bethesda Maryland USA"},{"name":"Department of Pathology Uniformed Services University, F. Edward Hebert School of Medicine  Bethesda Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Perl","sequence":"additional","affiliation":[{"name":"Department of Defense\/Uniformed Services University Brain Tissue Repository F. Edward Hebert School of Medicine  Bethesda Maryland USA"},{"name":"Department of Pathology Uniformed Services University, F. Edward Hebert School of Medicine  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurenai","family":"Tanji","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center, and the New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-8936","authenticated-orcid":false,"given":"James E.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center, and the New York Presbyterian Hospital  New York New York USA"},{"name":"The Taub Center for Research in Alzheimer's Disease and Aging  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab434"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-1136(19990215)25:4<324::aid-glia2>3.0.co;2-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlac030"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"113","article-title":"Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. 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