{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:49:07Z","timestamp":1792043347732,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain Pathology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive head impacts, experienced most commonly in contact sports; however, its relationship with prion diseases remains unclear. Postmortem CTE screening using phosphorylated tau staining was conducted at the Neurological Tissue Bank of Hospital Cl\u00ednic\u2010IDIBAPS on hippocampal and frontal cortex samples from patients with neuropathologically confirmed Creutzfeldt\u2013Jakob disease (CJD), blinded to patients' clinical histories. In positive and suggestive cases, the analysis was expanded in accordance with the NINDS\/NIBIB consensus criteria for CTE, and clinical and neuropathological information was reviewed. CTE was detected in 3 out of 212 CJD cases (1.4%), all with severe CTE pathology: 2 former soccer players (one of them an elite player) and 1 former rugby player. All had started playing sports between the first and second decades of life and ended in the fifth. The clinical presentation of CJD was heterogeneous, with different initial symptoms in each case. Neuropathological examination revealed an MM1\/MV1 histotype in the soccer players and a VV2 histotype in the rugby player, the first\u2010 and second\u2010most common variants in CJD, respectively. These three cases illustrate the coexistence of CTE and CJD across heterogeneous clinicopathological presentations. Further studies are needed to determine whether shared mechanisms may contribute to the coexistence of both pathologies.<\/jats:p>","DOI":"10.1111\/bpa.70156","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:35:17Z","timestamp":1792042517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt\u2013Jakob disease cohort"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1828-5424","authenticated-orcid":false,"given":"Lluc","family":"Bertran","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Science Hospital Cl\u00ednic, Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5774-7453","authenticated-orcid":false,"given":"Iban","family":"Aldecoa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biomedical Diagnostic Center (CDB) Hospital Cl\u00ednic, Universitat de Barcelona  Barcelona Spain"},{"name":"Neurological Tissue Bank Biobank\u2010Hospital Cl\u00ednic\u2010FRCB\u2010IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1210-9132","authenticated-orcid":false,"given":"Arl\u00e8ne","family":"Sindikubwabo","sequence":"additional","affiliation":[{"name":"Department of Health Care HOGENT University of Applied Sciences and Arts  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biomedical Diagnostic Center (CDB) Hospital Cl\u00ednic, Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Blesa","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit Hospital de la Santa Creu i Sant Pau \u2013 Biomedical Research Institute Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Mart\u00ednez\u2010Corral","sequence":"additional","affiliation":[{"name":"Neurology Department HM Sant Jordi Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-4910","authenticated-orcid":false,"given":"Carlos","family":"Nos","sequence":"additional","affiliation":[{"name":"Department of Public Health in Catalonia General Subdirectorate of Surveillance and Response to Emergencies in Public Health  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Santiago","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank Biobank\u2010Hospital Cl\u00ednic\u2010FRCB\u2010IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank Biobank\u2010Hospital Cl\u00ednic\u2010FRCB\u2010IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-8271","authenticated-orcid":false,"given":"\u00c1lex","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Sleep Unit, Neurology Service, FRCB\u2010IDIBAPS, CIBERNED CB06\/05\/0018\u2010ISCIII Hospital Cl\u00ednic, Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Nowinski","sequence":"additional","affiliation":[{"name":"Boston University Alzheimer's Disease Research Center and Boston University CTE Center, Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Concussion &amp; CTE Foundation  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-7488","authenticated-orcid":false,"given":"Ann C.","family":"McKee","sequence":"additional","affiliation":[{"name":"Boston University Alzheimer's Disease Research Center and Boston University CTE Center, Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel S\u00e1nchez","family":"Valle","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, FRCB\u2010IDIBAPS, CIBERNED CB24\/05\/0004 ISCIII Hospital Cl\u00ednic, Universitat de Barcelona, Institut de Neuroci\u00e8ncies  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-8578","authenticated-orcid":false,"given":"Laura","family":"Molina\u2010Porcel","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank Biobank\u2010Hospital Cl\u00ednic\u2010FRCB\u2010IDIBAPS  Barcelona Spain"},{"name":"Sant Pau Memory Unit Hospital de la Santa Creu i Sant Pau \u2013 Biomedical Research Institute Sant Pau  Barcelona Spain"},{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, FRCB\u2010IDIBAPS, CIBERNED CB24\/05\/0004 ISCIII Hospital Cl\u00ednic, Universitat de Barcelona, Institut de Neuroci\u00e8ncies  Barcelona 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