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It is mainly used in the treatment of acne vulgaris and some sexually transmitted diseases. Recently, it has been reported that tetracyclines can exert a variety of biological actions that are independent of their anti\u2010microbial activity, including anti\u2010inflammatory and anti\u2010apoptotic activities, and inhibition of proteolysis, angiogenesis and tumour metastasis. These findings specifically concern to minocycline as it has recently been found to have multiple non\u2010antibiotic biological effects that are beneficial in experimental models of various diseases with an inflammatory basis, including dermatitis, periodontitis, atherosclerosis and autoimmune disorders such as rheumatoid arthritis and inflammatory bowel disease. Of note, minocycline has also emerged as the most effective tetracycline derivative at providing neuroprotection. This effect has been confirmed in experimental models of ischaemia, traumatic brain injury and neuropathic pain, and of several neurodegenerative conditions including\n                    <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    arkinson's disease,\n                    <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                    untington's disease, amyotrophic lateral sclerosis,\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    lzheimer's disease, multiple sclerosis and spinal cord injury. Moreover, other pre\u2010clinical studies have shown its ability to inhibit malignant cell growth and activation and replication of human immunodeficiency virus, and to prevent bone resorption. Considering the above\u2010mentioned findings, this review will cover the most important topics in the pharmacology of minocycline to date, supporting its evaluation as a new therapeutic approach for many of the diseases described herein.\n                  <\/jats:p>","DOI":"10.1111\/bph.12139","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T12:39:33Z","timestamp":1361882373000},"page":"337-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":864,"title":["Minocycline: far beyond an antibiotic"],"prefix":"10.1111","volume":"169","author":[{"given":"N","family":"Garrido\u2010Mesa","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas en Red \u2013 Enfermedades Hep\u00e1ticas y Digestivas (CIBER\u2010EHD) Department of Pharmacology Center for Biomedical Research University of Granada  Granada 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